Detailed information of TA system TA171126

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 2055193..2055585
• Replicon: chromosome
• Accession: NZ_CP060844
• Organism: Salmonella enterica strain 770

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAR33_RS09670
• Protein ID: WP_000994223.1
• Coordinates: 2055193..2055438 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2055229..2055585 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR33_RS09660	2050478..2054584	+	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-
IAR33_RS09665	2054584..2055126	+	543	WP_079984650.1	hypothetical protein	-
IAR33_RS09670	2055193..2055438	-	246	WP_000994223.1	hypothetical protein	Toxin
-	2055229..2055585	+	357	-	-	Antitoxin
IAR33_RS09675	2055636..2056055	+	420	WP_131040133.1	hypothetical protein	-
IAR33_RS09680	2056873..2057340	+	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAR33_RS09685	2057658..2057936	+	279	WP_133323248.1	hypothetical protein	-
IAR33_RS09690	2058003..2058317	-	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAR33_RS09695	2058370..2059074	+	705	Protein_1879	integrase core domain-containing protein	-
IAR33_RS09700	2059836..2060333	+	498	WP_165963407.1	pilus assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2055193..2068976	13783

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171126 WP_000994223.1 NZ_CP060844:c2055438-2055193 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171126 NZ_CP077853:c68890-68795 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 357 bp

>AT171126 NZ_CP060844:2055229-2055585 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin