Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3212882..3213390 Replicon chromosome
Accession NZ_CP060825
Organism Streptomyces sp. CRPJ-33

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IAG43_RS13970 Protein ID WP_187741079.1
Coordinates 3213130..3213390 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag IAG43_RS13965 Protein ID WP_187741078.1
Coordinates 3212882..3213133 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG43_RS13935 3208551..3209249 - 699 WP_187741072.1 hypothetical protein -
IAG43_RS13940 3209263..3209562 - 300 WP_187741073.1 hypothetical protein -
IAG43_RS13945 3209577..3210122 - 546 WP_187741074.1 hypothetical protein -
IAG43_RS13950 3210142..3211893 - 1752 WP_187741075.1 hypothetical protein -
IAG43_RS13955 3211893..3212195 - 303 WP_187741076.1 WXG100 family type VII secretion target -
IAG43_RS13960 3212210..3212602 - 393 WP_187741077.1 WXG100 family type VII secretion target -
IAG43_RS13965 3212882..3213133 + 252 WP_187741078.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IAG43_RS13970 3213130..3213390 + 261 WP_187741079.1 Txe/YoeB family addiction module toxin Toxin
IAG43_RS13975 3213489..3215111 - 1623 WP_187741080.1 chaperonin GroEL -
IAG43_RS13980 3215553..3215756 - 204 WP_005315736.1 cold-shock protein -
IAG43_RS13985 3216189..3216467 - 279 WP_187741081.1 MoaD/ThiS family protein -
IAG43_RS13990 3216464..3217783 - 1320 WP_187741082.1 threonine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10406.74 Da        Isoelectric Point: 8.8722

>T171062 WP_187741079.1 NZ_CP060825:3213130-3213390 [Streptomyces sp. CRPJ-33]
VKFVWDESSWGDYVWWQAQDRKVLKRINTLLQDIARNGNEGIGKPEPLKHGFQGYWSRRITDEHRLVYKIVDDEIRVAAC
RYHYER

Download         Length: 261 bp

>T171062 NZ_CP077823:c2637437-2636115 [Klebsiella africana]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGTGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCGCTCTCGCTGCCGCTGCAGTATGGCAATATCACTG
CCGATGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCAAAGCAGCCGTTCGATCTACTGGCCGAAGTTGGGCGCGATAGCGTAGGGGCGGTAACCCTCCTGCCGCCGGG
GGAAGAGGCGCATCTGGAGGCGTTGCGCTGGCAGACGCTGGACGAGGCGCAGCTCACCTCTCTGCTGACCGCCTACCAGT
CGGATATTCCCCTCGGGATGATTACCGGCCAGGATGATTTCCGTATCTCGGTGGCTGGCGCCCAGGAGAAAACGGCGCTG
CTGCGAATGGGCGATCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAGCTGCCGATCGGCGAGAT
AAAGCAGCCGAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTATCTGTGCCTGACGCTGGCCAGAGAACTTG
GCCTGGCGGTGCCGGAGGCGGAGATCATCACCACCCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGTCTTCCTTCAGCGATGAAATA
TGAATCTGACGGCGGGCCGGGGATCGCCGCGATGATGTCTTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGACCGCAATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTATGGCGACCGCCAAAGCGGTGAATTTTCCTCGGGAGCAGATGCTGGCCATCCTCCAGGAGTTTGCTGAGCGCGTGCCG
CAGACTATTGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCAGGCCATTACAGAGAATGTGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGTTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9328.54 Da        Isoelectric Point: 4.6802

>AT171062 WP_187741078.1 NZ_CP060825:3212882-3213133 [Streptomyces sp. CRPJ-33]
MRTMTYTESRAKYAETLNAVVDDREEVIVTRAGREPVVIVALAEYESLKETAYLLRSPENARRLLASIDRLENGGGTVRE
LAE

Download         Length: 252 bp

>AT171062 NZ_CP077823:c2637703-2637437 [Klebsiella africana]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAGCTACCTGAAGCTGCTGCGCCAGCAGAATCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACACTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAAGCCACAGAGACGGCCCCGGCTCCT
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References