Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 488126..488715 Replicon chromosome
Accession NZ_CP060718
Organism Sphingomonas lutea strain KCTC 23642

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H9L13_RS02515 Protein ID WP_187538746.1
Coordinates 488126..488419 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H9L13_RS02520 Protein ID WP_187538748.1
Coordinates 488419..488715 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L13_RS02495 484081..484389 - 309 WP_187538738.1 hypothetical protein -
H9L13_RS02500 484455..486818 - 2364 WP_187538740.1 PAS domain S-box protein -
H9L13_RS02505 486884..487858 + 975 WP_187538742.1 hypothetical protein -
H9L13_RS02510 487855..488061 + 207 WP_187538744.1 hypothetical protein -
H9L13_RS02515 488126..488419 + 294 WP_187538746.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9L13_RS02520 488419..488715 + 297 WP_187538748.1 putative addiction module antidote protein Antitoxin
H9L13_RS02525 488819..490150 + 1332 WP_187538750.1 hypothetical protein -
H9L13_RS02530 490122..490484 + 363 WP_187538752.1 DUF2384 domain-containing protein -
H9L13_RS02535 490563..491030 + 468 WP_187540071.1 RES family NAD+ phosphorylase -
H9L13_RS02540 491359..493278 - 1920 WP_187538754.1 translation elongation factor 4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10688.22 Da        Isoelectric Point: 7.9698

>T170857 WP_187538746.1 NZ_CP060718:488126-488419 [Sphingomonas lutea]
MIEVRQTTRFSTWLAGLRDERARARILKRLDRAGQGNLGDVAPVGEGVSEMRIFYGPGYRVYFVQRGSALIVLLCGGDKA
TQNADIAEAKAMAEELD

Download         Length: 294 bp

>T170857 NZ_CP077755:2298924-2299190 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10487.82 Da        Isoelectric Point: 4.4805

>AT170857 WP_187538748.1 NZ_CP060718:488419-488715 [Sphingomonas lutea]
MPKIETTKFDSADYLNTAEAIAAYLDAYLEDATPEELRGALATVARSHGISDLARRSGVSRPGIYKALGEDGNPSFETIR
SILGAMGLRLTIEPAEMG

Download         Length: 297 bp

>AT170857 NZ_CP077755:2298667-2298924 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References