Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-couple_hipB
Location 5119292..5119902 Replicon chromosome
Accession NZ_CP060714
Organism Diaphorobacter ruginosibacter strain DSM 27467

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H9K76_RS23095 Protein ID WP_187597564.1
Coordinates 5119576..5119902 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H9K76_RS23090 Protein ID WP_187597563.1
Coordinates 5119292..5119579 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9K76_RS23070 5114524..5115810 - 1287 WP_187597560.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
H9K76_RS23075 5115838..5116749 - 912 WP_187597561.1 hypothetical protein -
H9K76_RS23080 5116746..5117822 - 1077 WP_187597562.1 GNAT family N-acetyltransferase -
H9K76_RS23085 5117822..5119197 - 1376 Protein_4531 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
H9K76_RS23090 5119292..5119579 - 288 WP_187597563.1 helix-turn-helix domain-containing protein Antitoxin
H9K76_RS23095 5119576..5119902 - 327 WP_187597564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9K76_RS23100 5120053..5121117 - 1065 WP_187597565.1 homocysteine S-methyltransferase family protein -
H9K76_RS23105 5121217..5122167 - 951 WP_187600810.1 tripartite tricarboxylate transporter substrate binding protein -
H9K76_RS23110 5122255..5123595 - 1341 WP_187597566.1 fumarylacetoacetase -
H9K76_RS23115 5123634..5124437 - 804 WP_187597567.1 3-hydroxybutyrate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-83)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12136.15 Da        Isoelectric Point: 10.9753

>T170854 WP_187597564.1 NZ_CP060714:c5119902-5119576 [Diaphorobacter ruginosibacter]
MNAWTVTIHPAASPELLSLPADMQARFLHIADMLEDFGPQRVGLPHVRPLRHKLWEMRLNGRDGIARVVYAAVQGRRLLV
LHAFVKKTQATPRSAIETALSRLEAHEA

Download         Length: 327 bp

>T170854 NZ_CP077745:c1705880-1705584 [Desulfovibrio desulfuricans]
ATGAGCTATAGTCTGCAGTTTCATGAGCTAGCACTGAAAGAATGGAAAAAGCTGGATGCCAGCATCAGAGAACAATTTAA
AAAGAAACTGGCAGAACGGTTACAGCAGCCGAGAGTTCCTTCATCTGCCCTGTCTGGCATGCGTGATTGCTACAAAATCA
AATTGCGCTCCATTGGGTATCGCCTAGTGTACAAGGTGAATGATGACATTCTCTTTGTAACGGTCATCTCCATTGGCAAG
CGTGAACGTCTTGAGGCATATCGACAAGCCCTACGACGCATGCCCTCTGAAGAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10475.09 Da        Isoelectric Point: 10.6579

>AT170854 WP_187597563.1 NZ_CP060714:c5119579-5119292 [Diaphorobacter ruginosibacter]
MKTLTSLKAEMLAQDDVRTHYESLADEFAMARELIAARTRAGLTQADVAARMGTTQSVIARIEGGKATPSLRSVQRYAEA
IGCRAVVRLERLPRR

Download         Length: 288 bp

>AT170854 NZ_CP077745:c1706115-1705870 [Desulfovibrio desulfuricans]
ATGGATTCCATACACTCCAATATCACCGTCAGCGTCACAGAACTCAAACGGAACTTTGCGAATGTCCTGGCAACTGCCAA
GGATGCGCCGGTGGCAGTTTTGAACCATAACAAGCCAGAGGCCTACTTGTTGTCCGCAAAGCACTACGAAGAAATCCTCG
GAATTCTCGAAGATCTTGAAGACAGAAAGGTTGTTGAAAAGCGCGAAGATGGCCCTTTTATCAAGGTAACGCTTGATGAG
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References