Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2730..4389 Replicon chromosome
Accession NZ_CP060714
Organism Diaphorobacter ruginosibacter strain DSM 27467

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H9K76_RS00015 Protein ID WP_187600376.1
Coordinates 3079..4389 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H9K76_RS00010 Protein ID WP_187597599.1
Coordinates 2730..3011 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9K76_RS00010 2730..3011 + 282 WP_187597599.1 helix-turn-helix domain-containing protein Antitoxin
H9K76_RS00015 3079..4389 + 1311 WP_187600376.1 type II toxin-antitoxin system HipA family toxin Toxin
H9K76_RS00020 4584..5981 - 1398 WP_187597600.1 glycerophosphodiester phosphodiesterase -
H9K76_RS00025 6271..6831 - 561 WP_187597601.1 TlpA family protein disulfide reductase -
H9K76_RS00030 7060..8268 - 1209 WP_187597602.1 tryptophan synthase subunit beta -
H9K76_RS00035 8397..9098 - 702 WP_187597603.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(1-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49363.63 Da        Isoelectric Point: 6.4222

>T170852 WP_187600376.1 NZ_CP060714:3079-4389 [Diaphorobacter ruginosibacter]
MNGRFVGTWSIEAGGDVLQYDAEWVNDPVLRRPLSLSLPFTPGNRPHKGDAVRFYFQNLLPDNEYILERIARRYRVRSID
AYSLLSEIGRDCVGALQILPAGDMPPEEQGVHREALDEAEMARLIRATIDPGLFGDSARDDEKFRISIAGAQEKTAFLRW
QGQWCRPLGATPTTHIFKLPLGLIGNMQFDMRHSVENEWLCSELLAAYGLPVARCEVLQFEDQKVLSVERFDRRVWNDSE
LLRLPQEDMCQAMGMPPILKYESDGGPGVDRIMALLDGSMNRDQDRLQFFTAQLLFWMLCATDGHAKNFSIFLRPEGRFE
LTPLYDVLSAYPILGAGPGKLSPHKARMAMAARSKNAHWHMNKIVRRHWVAVGERYGIVSRQGMPVDAVIDEIVEMTPTV
VQRVRGKLPEGFPQEVAEAIFNGLLEAARRLGRSRD

Download         Length: 1311 bp

>T170852 NZ_CP077741:c2223858-2223496 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10389.08 Da        Isoelectric Point: 11.0968

>AT170852 WP_187597599.1 NZ_CP060714:2730-3011 [Diaphorobacter ruginosibacter]
MDEFTVRTTEQLPQLLKAFRKNAKLTQADVALRLGVTQQTVSAMERNAETVSAERLMKLMGILGVDLVLRARTSQAAPLA
QPGHMVNESRPRW

Download         Length: 282 bp

>AT170852 NZ_CP077741:c2224025-2223855 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References