Detailed information of TA system TA170840

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3862373..3862595
• Replicon: chromosome
• Accession: NZ_CP060709
• Organism: Escherichia coli strain ST18

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: H9445_RS19020
• Protein ID: WP_000141634.1
• Coordinates: 3862373..3862480 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3862529..3862595 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9445_RS18995	3857626..3858378	-	753	Protein_3717	cellulose biosynthesis protein BcsQ	-
H9445_RS19000	3858390..3858578	-	189	WP_001063318.1	YhjR family protein	-
H9445_RS19005	3858851..3860422	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
H9445_RS19010	3860419..3860610	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
H9445_RS19015	3860607..3862286	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
H9445_RS19020	3862373..3862480	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3862529..3862595	+	67	-	-	Antitoxin
H9445_RS19025	3862956..3864227	+	1272	WP_001295225.1	transporter	-
H9445_RS19030	3864257..3865261	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
H9445_RS19035	3865258..3866241	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
H9445_RS19040	3866252..3867154	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T170840 WP_000141634.1 NZ_CP060709:c3862480-3862373 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T170840 NZ_CP077723:c931117-930824 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT170840 NZ_CP060709:3862529-3862595 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin