Detailed information of TA system TA170761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 5459688..5460294
• Replicon: chromosome
• Accession: NZ_CP060704
• Organism: Chitinimonas koreensis strain R2A43-10

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: H9L41_RS23270
• Protein ID: WP_028447424.1
• Coordinates: 5459688..5459978 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H9L41_RS23275
• Protein ID: WP_028447423.1
• Coordinates: 5459989..5460294 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L41_RS25350	5456401..5456580	+	180	WP_265583887.1	hypothetical protein	-
H9L41_RS23260 (H9L41_23260)	5456598..5457320	+	723	WP_265583888.1	alpha/beta fold hydrolase	-
H9L41_RS23265 (H9L41_23265)	5457548..5459575	+	2028	WP_028447425.1	NADPH-dependent 2,4-dienoyl-CoA reductase	-
H9L41_RS23270 (H9L41_23270)	5459688..5459978	+	291	WP_028447424.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H9L41_RS23275 (H9L41_23275)	5459989..5460294	+	306	WP_028447423.1	putative addiction module antidote protein	Antitoxin
H9L41_RS23280 (H9L41_23280)	5460471..5462825	+	2355	WP_028447422.1	hypothetical protein	-
H9L41_RS23285 (H9L41_23285)	5463039..5463524	+	486	WP_028447421.1	DUF2314 domain-containing protein	-
H9L41_RS23290 (H9L41_23290)	5463829..5464173	+	345	WP_245589242.1	hypothetical protein	-
H9L41_RS23295 (H9L41_23295)	5464268..5464504	+	237	WP_157462090.1	glyoxalase superfamily protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (3-95)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10749.27 Da
• Isoelectric Point: 10.8743

>T170761 WP_028447424.1 NZ_CP060704:5459688-5459978 [Chitinimonas koreensis]
MVEIRQTDGYAHWFAGLRDRTARARIDIRIRRLSLDNPGDVKPVGGGVSELRIDRGPGYRIYFVRRGDTLVVLLAGGGKS
TQEQDIRNALELARSI

Nucleotide

• Length: 291 bp

>T170761 NZ_CP077699:2104662-2104765 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10578.03 Da
• Isoelectric Point: 4.6263

>AT170761 WP_028447423.1 NZ_CP060704:5459989-5460294 [Chitinimonas koreensis]
MADTATRAWDPAEHLDSEEDMAAYLEAALEDGDPALVTAALGDIARAKGMTRIAREAGLSRESLYKALSPNGNPELATIL
KVVSVLGLRLHATPAPAKLPG

Nucleotide

• Length: 306 bp

>AT170761 NZ_CP077699:c2104767-2104624 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG