Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1412789..1413381 Replicon chromosome
Accession NZ_CP060693
Organism Aliarcobacter cryaerophilus strain 16CS1285-4

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S9SLA8
Locus tag HOO34_RS07400 Protein ID WP_066161635.1
Coordinates 1412789..1413037 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4V1LB08
Locus tag HOO34_RS07405 Protein ID WP_066351012.1
Coordinates 1413037..1413381 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOO34_RS07385 1408021..1410297 + 2277 WP_187474025.1 methyl-accepting chemotaxis protein -
HOO34_RS07390 1410333..1411460 - 1128 WP_187474026.1 iron-containing alcohol dehydrogenase -
HOO34_RS07395 1411584..1412744 + 1161 WP_187474027.1 pyridoxal phosphate-dependent aminotransferase -
HOO34_RS07400 1412789..1413037 + 249 WP_066161635.1 type II toxin-antitoxin system HicA family toxin Toxin
HOO34_RS07405 1413037..1413381 + 345 WP_066351012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HOO34_RS07410 1413403..1414077 - 675 WP_187474028.1 virulence RhuM family protein -
HOO34_RS07415 1414070..1414831 - 762 WP_187475294.1 competence/damage-inducible protein A -
HOO34_RS07420 1414844..1415416 - 573 WP_187474029.1 adenylate kinase -
HOO34_RS07425 1415629..1416270 + 642 WP_187474030.1 adenylate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-79)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9572.47 Da        Isoelectric Point: 10.3374

>T170735 WP_066161635.1 NZ_CP060693:1412789-1413037 [Aliarcobacter cryaerophilus]
MSKKDKLLLKFLENPPKKDLTFKELNTLLTYLGFIKIEGAGSAVKFYNKDKDLLINLHKPHPSDILKVYLIKQIQNKLKE
FL

Download         Length: 249 bp

>T170735 NZ_CP077693:c2979159-2979004 [Salmonella enterica subsp. enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTATCACCGTTGTAATGGCGGTGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGCATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACGGCTTACGAATCTGAGGAGTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12974.76 Da        Isoelectric Point: 4.7253

>AT170735 WP_066351012.1 NZ_CP060693:1413037-1413381 [Aliarcobacter cryaerophilus]
MANIIEYNGYIGTIEYSQEDKCFFGKIDMINDLVTFEAQNATELEENFKNAVDEYILTCKELNREPQKAFKGVFNVRTGS
ELHKLAVLNATKIGVSLNTYIKNLIEKDSKLSLN

Download         Length: 345 bp

>AT170735 NZ_CP077693:2979171-2979229 [Salmonella enterica subsp. enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9SLA8

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1LB08

References