Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4673077..4673837 Replicon chromosome
Accession NZ_CP060678
Organism Salmonella enterica strain 190610_1

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag H9Q82_RS22705 Protein ID WP_000533912.1
Coordinates 4673077..4673562 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag H9Q82_RS22710 Protein ID WP_000965886.1
Coordinates 4673550..4673837 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q82_RS22675 (4668149) 4668149..4668811 + 663 WP_000747548.1 OmpA family lipoprotein -
H9Q82_RS22680 (4669030) 4669030..4670004 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
H9Q82_RS22685 (4670054) 4670054..4670764 - 711 WP_000190524.1 DUF3053 domain-containing protein -
H9Q82_RS22690 (4671203) 4671203..4671493 + 291 WP_000455790.1 HTH-type transcriptional regulator -
H9Q82_RS22695 (4671781) 4671781..4671993 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
H9Q82_RS22700 (4672167) 4672167..4672706 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
H9Q82_RS22705 (4673077) 4673077..4673562 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
H9Q82_RS22710 (4673550) 4673550..4673837 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
H9Q82_RS22715 (4674015) 4674015..4674482 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
H9Q82_RS22720 (4674654) 4674654..4675052 - 399 Protein_4422 IS3 family transposase -
H9Q82_RS22725 (4675442) 4675442..4677511 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
H9Q82_RS22730 (4677521) 4677521..4678432 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4663644..4674482 10838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T170730 WP_000533912.1 NZ_CP060678:c4673562-4673077 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T170730 NZ_CP077692:c118109-117693 [Salmonella enterica subsp. enterica]
GTGAACAAAACGTATATGCTGGATACCAATATCTGCTCATTCATCATGCGTGAGCAGCCGAAGGCCGTGATCAGACGCTT
AGAGCAAGCGGTGCTGCGCAACCATCGCATCGTGGTCTCCGCTATTACCTACGCCGAAATGCGCTTCGGTGCTATCGGGA
AAAAGGCCTCGCCCCGTCATGGCCAACTGGTCGATGCGTTCTGCGCCCGCCTCGATGCGATTCTGCCGTGGGACCGTGCC
GCAGTCGATGCCACTGTAGAGGTCAAAGCAGCACTAACCGCAGCCGGTACACCCATCGGTCCCAACGACACAGCGATTGC
CGGACATGCTATAGCTGCAGGGGCCATTCTGGTGACCAATAATACGCGAGAGTTTGAGCGGGTGCCAAATTTGGTATTAG
AAGACTGGGTTAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT170730 WP_000965886.1 NZ_CP060678:c4673837-4673550 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT170730 NZ_CP077692:c118336-118106 [Salmonella enterica subsp. enterica]
ATGCGAACAGTATCTATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCTCGCGATTTGGATTTTGAAGGGGTGAG
TGAGTTGGAGATTGTCCGAGAAGGGGACAGCATCATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
AAAAGGCCGACGCAGACTTTTTGGTGGAGCGTGAAGACGTGGTCAGTGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References