Detailed information of TA system TA170677

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 693188..693413
• Replicon: chromosome
• Accession: NZ_CP060676
• Organism: Salmonella enterica strain 190704_2

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: H9Q83_RS03690
• Protein ID: WP_000813254.1
• Coordinates: 693188..693343 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	693355..693413 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q83_RS03655	688295..688576	-	282	WP_000445513.1	phage holin family protein	-
H9Q83_RS03660	688566..688754	-	189	WP_001688615.1	putative holin	-
H9Q83_RS03665	688748..689071	-	324	Protein_720	tellurite/colicin resistance protein	-
H9Q83_RS03670	691242..691778	-	537	WP_000640113.1	DUF1133 family protein	-
H9Q83_RS03675	691775..692065	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
H9Q83_RS03680	692065..692664	-	600	WP_000940751.1	DUF1367 family protein	-
H9Q83_RS03685	692727..692897	-	171	WP_000734094.1	hypothetical protein	-
H9Q83_RS03690	693188..693343	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	693355..693413	+	59	-	-	Antitoxin
H9Q83_RS03695	693770..694702	+	933	WP_000556390.1	hypothetical protein	-
H9Q83_RS03700	694699..695253	+	555	WP_001033796.1	hypothetical protein	-
H9Q83_RS03705	695415..695744	-	330	WP_001676916.1	DUF977 family protein	-
H9Q83_RS03710	695788..695835	-	48	Protein_729	hypothetical protein	-
H9Q83_RS03715	696017..696484	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
H9Q83_RS03720	696869..697024	+	156	WP_085981757.1	DUF1391 family protein	-
H9Q83_RS03725	697132..697653	-	522	WP_000004762.1	super-infection exclusion protein B	-
H9Q83_RS03730	698091..698312	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	687753..699624	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T170677 WP_000813254.1 NZ_CP060676:c693343-693188 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T170677 NZ_CP077673:c1385000-1384782 [Klebsiella sp. PL-2018]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT170677 NZ_CP060676:693355-693413 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin