Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3903152..3903690 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag H9Q84_RS19145 Protein ID WP_001526148.1
Coordinates 3903152..3903427 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag H9Q84_RS19150 Protein ID WP_000729713.1
Coordinates 3903430..3903690 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS19140 (3900359) 3900359..3903064 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
H9Q84_RS19145 (3903152) 3903152..3903427 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
H9Q84_RS19150 (3903430) 3903430..3903690 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H9Q84_RS19155 (3903799) 3903799..3904818 - 1020 WP_000101024.1 RNA 3'-terminal phosphate cyclase -
H9Q84_RS19160 (3904822) 3904822..3906036 - 1215 WP_001105533.1 RNA-splicing ligase RtcB -
H9Q84_RS19165 (3906384) 3906384..3907937 - 1554 WP_000013013.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T170670 WP_001526148.1 NZ_CP060674:c3903427-3903152 [Salmonella enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T170670 NZ_CP077670:4498231-4498542 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT170670 WP_000729713.1 NZ_CP060674:c3903690-3903430 [Salmonella enterica]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT170670 NZ_CP077670:4498539-4498985 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References