Detailed information of TA system TA170665

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1817405..1817630
• Replicon: chromosome
• Accession: NZ_CP060674
• Organism: Salmonella enterica strain 190729_4

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: H9Q84_RS08875
• Protein ID: WP_000813254.1
• Coordinates: 1817475..1817630 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1817405..1817463 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q84_RS08835	1812506..1812727	-	222	WP_000560208.1	cell division protein FtsZ	-
H9Q84_RS08840	1813165..1813686	+	522	WP_000004762.1	super-infection exclusion protein B	-
H9Q84_RS08845	1813794..1813949	-	156	WP_085981757.1	DUF1391 family protein	-
H9Q84_RS08850	1814334..1814801	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
H9Q84_RS08855	1814983..1815030	+	48	Protein_1726	hypothetical protein	-
H9Q84_RS08860	1815074..1815403	+	330	WP_001676916.1	DUF977 family protein	-
H9Q84_RS08865	1815565..1816119	-	555	WP_001033796.1	hypothetical protein	-
H9Q84_RS08870	1816116..1817048	-	933	WP_000556390.1	hypothetical protein	-
-	1817405..1817463	-	59	-	-	Antitoxin
H9Q84_RS08875	1817475..1817630	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
H9Q84_RS08880	1817921..1818091	+	171	WP_000734094.1	hypothetical protein	-
H9Q84_RS08885	1818154..1818753	+	600	WP_000940751.1	DUF1367 family protein	-
H9Q84_RS08890	1818753..1819043	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
H9Q84_RS08895	1819040..1819576	+	537	WP_000640113.1	DUF1133 family protein	-
H9Q84_RS08900	1821747..1822070	+	324	Protein_1735	tellurite/colicin resistance protein	-
H9Q84_RS08905	1822064..1822252	+	189	WP_001688615.1	putative holin	-
H9Q84_RS08910	1822242..1822523	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1811194..1823065	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T170665 WP_000813254.1 NZ_CP060674:1817475-1817630 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T170665 NZ_CP077670:2364374-2364658 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGGAACGACTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT170665 NZ_CP060674:c1817463-1817405 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin