Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 228834..229384 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag H9Q84_RS01085 Protein ID WP_001199743.1
Coordinates 229076..229384 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag H9Q84_RS01080 Protein ID WP_001118105.1
Coordinates 228834..229073 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS01045 (224273) 224273..225304 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
H9Q84_RS01050 (225521) 225521..226051 + 531 WP_000896758.1 gluconokinase -
H9Q84_RS01055 (226079) 226079..227098 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
H9Q84_RS01065 (227855) 227855..228286 + 432 Protein_207 helix-turn-helix domain-containing protein -
H9Q84_RS01070 (228317) 228317..228400 + 84 WP_228958541.1 DUF4942 domain-containing protein -
H9Q84_RS01075 (228477) 228477..228725 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
H9Q84_RS01080 (228834) 228834..229073 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H9Q84_RS01085 (229076) 229076..229384 + 309 WP_001199743.1 CcdB family protein Toxin
H9Q84_RS01090 (229790) 229790..229930 + 141 Protein_212 Arm DNA-binding domain-containing protein -
H9Q84_RS01095 (229962) 229962..231095 - 1134 Protein_213 IS3 family transposase -
H9Q84_RS01100 (231418) 231418..231948 + 531 WP_234909759.1 SEF14 fimbria major subunit SefA -
H9Q84_RS01105 (232070) 232070..232810 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 227900..231003 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T170651 WP_001199743.1 NZ_CP060674:229076-229384 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T170651 NZ_CP077668:2533989-2534273 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT170651 WP_001118105.1 NZ_CP060674:228834-229073 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT170651 NZ_CP077668:2533751-2533999 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References