Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 80582..81363 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q84_RS00295 Protein ID WP_000626100.1
Coordinates 80872..81363 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q84_RS00290 Protein ID WP_001110452.1
Coordinates 80582..80875 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS00255 (76629) 76629..77534 + 906 WP_001268200.1 YjiK family protein -
H9Q84_RS00260 (77828) 77828..77959 - 132 Protein_51 hypothetical protein -
H9Q84_RS00265 (78071) 78071..78319 - 249 Protein_52 Ig-like domain-containing protein -
H9Q84_RS00270 (78444) 78444..78626 + 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
H9Q84_RS00275 (78619) 78619..78906 - 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q84_RS00280 (78903) 78903..79778 - 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q84_RS00285 (80044) 80044..80265 - 222 WP_001576552.1 hypothetical protein -
H9Q84_RS00290 (80582) 80582..80875 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q84_RS00295 (80872) 80872..81363 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q84_RS00300 (81611) 81611..82363 - 753 WP_000842433.1 non-specific acid phosphatase -
H9Q84_RS00305 (82463) 82463..82540 - 78 Protein_60 porin family protein -
H9Q84_RS00310 (82920) 82920..82994 + 75 Protein_61 helix-turn-helix domain-containing protein -
H9Q84_RS00320 (83265) 83265..83840 - 576 WP_001188509.1 transcriptional regulator -
H9Q84_RS00325 (83877) 83877..85580 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q84_RS00330 (85556) 85556..85903 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170649 WP_000626100.1 NZ_CP060674:80872-81363 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170649 NZ_CP077668:c1028543-1028016 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170649 WP_001110452.1 NZ_CP060674:80582-80875 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170649 NZ_CP077668:c1028830-1028540 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References