Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4579060..4579610 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag H9Q86_RS22250 Protein ID WP_001199743.1
Coordinates 4579302..4579610 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag H9Q86_RS22245 Protein ID WP_001118105.1
Coordinates 4579060..4579299 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS22210 (4574499) 4574499..4575530 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
H9Q86_RS22215 (4575747) 4575747..4576277 + 531 WP_000896758.1 gluconokinase -
H9Q86_RS22220 (4576305) 4576305..4577324 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
H9Q86_RS22230 (4578081) 4578081..4578512 + 432 Protein_4327 helix-turn-helix domain-containing protein -
H9Q86_RS22235 (4578543) 4578543..4578626 + 84 WP_228958541.1 DUF4942 domain-containing protein -
H9Q86_RS22240 (4578703) 4578703..4578951 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
H9Q86_RS22245 (4579060) 4579060..4579299 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H9Q86_RS22250 (4579302) 4579302..4579610 + 309 WP_001199743.1 CcdB family protein Toxin
H9Q86_RS22255 (4580016) 4580016..4580156 + 141 Protein_4332 Arm DNA-binding domain-containing protein -
H9Q86_RS22260 (4580188) 4580188..4581321 - 1134 Protein_4333 IS3 family transposase -
H9Q86_RS22265 (4581644) 4581644..4582174 + 531 WP_234909759.1 SEF14 fimbria major subunit SefA -
H9Q86_RS22270 (4582296) 4582296..4583036 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4579060..4599553 20493
- inside IScluster/Tn - - 4578126..4581229 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T170617 WP_001199743.1 NZ_CP060670:4579302-4579610 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T170617 NZ_CP077660:3743523-3743741 [Enterobacter cloacae complex sp. ECL78]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT170617 WP_001118105.1 NZ_CP060670:4579060-4579299 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT170617 NZ_CP077660:3743121-3743495 [Enterobacter cloacae complex sp. ECL78]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGCCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References