Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4121862..4122464 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag H9Q86_RS20110 Protein ID WP_001159635.1
Coordinates 4121862..4122173 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H9Q86_RS20115 Protein ID WP_000362050.1
Coordinates 4122174..4122464 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS20075 (4116975) 4116975..4117574 + 600 WP_000965695.1 glucose-1-phosphatase -
H9Q86_RS20080 (4117568) 4117568..4118440 + 873 WP_000921423.1 virulence factor BrkB family protein -
H9Q86_RS20085 (4118437) 4118437..4118874 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
H9Q86_RS20090 (4118919) 4118919..4119860 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
H9Q86_RS20095 (4119875) 4119875..4120321 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
H9Q86_RS20100 (4120318) 4120318..4120629 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
H9Q86_RS20105 (4120715) 4120715..4121644 - 930 WP_001127705.1 alpha/beta hydrolase -
H9Q86_RS20110 (4121862) 4121862..4122173 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
H9Q86_RS20115 (4122174) 4122174..4122464 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
H9Q86_RS20120 (4122511) 4122511..4123440 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
H9Q86_RS20125 (4123437) 4123437..4124072 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
H9Q86_RS20130 (4124069) 4124069..4124971 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T170614 WP_001159635.1 NZ_CP060670:4121862-4122173 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T170614 NZ_CP077660:2019389-2019492 [Enterobacter cloacae complex sp. ECL78]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT170614 WP_000362050.1 NZ_CP060670:4122174-4122464 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT170614 NZ_CP077660:c2019499-2019296 [Enterobacter cloacae complex sp. ECL78]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTG
GTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References