Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3730189..3730949 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag H9Q86_RS18245 Protein ID WP_000533912.1
Coordinates 3730189..3730674 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag H9Q86_RS18250 Protein ID WP_000965886.1
Coordinates 3730662..3730949 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS18215 (3725261) 3725261..3725923 + 663 WP_000747548.1 OmpA family lipoprotein -
H9Q86_RS18220 (3726142) 3726142..3727116 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
H9Q86_RS18225 (3727166) 3727166..3727876 - 711 WP_000190524.1 DUF3053 domain-containing protein -
H9Q86_RS18230 (3728315) 3728315..3728605 + 291 WP_000455790.1 HTH-type transcriptional regulator -
H9Q86_RS18235 (3728893) 3728893..3729105 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
H9Q86_RS18240 (3729279) 3729279..3729818 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
H9Q86_RS18245 (3730189) 3730189..3730674 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
H9Q86_RS18250 (3730662) 3730662..3730949 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
H9Q86_RS18255 (3731127) 3731127..3731594 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
H9Q86_RS18260 (3731766) 3731766..3732164 - 399 Protein_3567 IS3 family transposase -
H9Q86_RS18265 (3732554) 3732554..3734623 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
H9Q86_RS18270 (3734633) 3734633..3735544 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3720756..3731594 10838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T170612 WP_000533912.1 NZ_CP060670:c3730674-3730189 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T170612 NZ_CP077659:4320141-4320512 [Enterobacter cloacae complex sp. ECL72]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT170612 WP_000965886.1 NZ_CP060670:c3730949-3730662 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT170612 NZ_CP077659:4319896-4320138 [Enterobacter cloacae complex sp. ECL72]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References