Detailed information of TA system TA170605

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1484492..1484717
• Replicon: chromosome
• Accession: NZ_CP060670
• Organism: Salmonella enterica strain 190807_1

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: H9Q86_RS07280
• Protein ID: WP_000813254.1
• Coordinates: 1484562..1484717 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1484492..1484550 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q86_RS07240	1479593..1479814	-	222	WP_000560208.1	cell division protein FtsZ	-
H9Q86_RS07245	1480252..1480773	+	522	WP_000004762.1	super-infection exclusion protein B	-
H9Q86_RS07250	1480881..1481036	-	156	WP_085981757.1	DUF1391 family protein	-
H9Q86_RS07255	1481421..1481888	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
H9Q86_RS07260	1482070..1482117	+	48	Protein_1415	hypothetical protein	-
H9Q86_RS07265	1482161..1482490	+	330	WP_001676916.1	DUF977 family protein	-
H9Q86_RS07270	1482652..1483206	-	555	WP_001033796.1	hypothetical protein	-
H9Q86_RS07275	1483203..1484135	-	933	WP_000556390.1	hypothetical protein	-
-	1484492..1484550	-	59	-	-	Antitoxin
H9Q86_RS07280	1484562..1484717	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
H9Q86_RS07285	1485008..1485178	+	171	WP_000734094.1	hypothetical protein	-
H9Q86_RS07290	1485241..1485840	+	600	WP_000940751.1	DUF1367 family protein	-
H9Q86_RS07295	1485840..1486130	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
H9Q86_RS07300	1486127..1486663	+	537	WP_000640113.1	DUF1133 family protein	-
H9Q86_RS07305	1488834..1489157	+	324	Protein_1424	tellurite/colicin resistance protein	-
H9Q86_RS07310	1489151..1489339	+	189	WP_001688615.1	putative holin	-
H9Q86_RS07315	1489329..1489610	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1454687..1490152	35465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T170605 WP_000813254.1 NZ_CP060670:1484562-1484717 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T170605 NZ_CP077659:c1839657-1839172 [Enterobacter cloacae complex sp. ECL72]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAGCGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT170605 NZ_CP060670:c1484550-1484492 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin