Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 515593..516213 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag H9Q86_RS02355 Protein ID WP_001280991.1
Coordinates 515593..515811 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag H9Q86_RS02360 Protein ID WP_000344807.1
Coordinates 515839..516213 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS02315 (510816) 510816..511385 + 570 WP_000779802.1 YbaY family lipoprotein -
H9Q86_RS02320 (511418) 511418..511807 - 390 WP_000961287.1 MGMT family protein -
H9Q86_RS02330 (512038) 512038..513588 - 1551 WP_000213140.1 EAL domain-containing protein -
H9Q86_RS02335 (513813) 513813..514073 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
H9Q86_RS02340 (514079) 514079..514219 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
H9Q86_RS02345 (514275) 514275..514745 - 471 WP_000136183.1 YlaC family protein -
H9Q86_RS02350 (514863) 514863..515414 - 552 WP_001278793.1 maltose O-acetyltransferase -
H9Q86_RS02355 (515593) 515593..515811 - 219 WP_001280991.1 HHA domain-containing protein Toxin
H9Q86_RS02360 (515839) 515839..516213 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
H9Q86_RS02365 (516709) 516709..519858 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
H9Q86_RS02370 (519881) 519881..521074 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T170596 WP_001280991.1 NZ_CP060670:c515811-515593 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T170596 NZ_CP077649:4516950-4517053 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT170596 WP_000344807.1 NZ_CP060670:c516213-515839 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT170596 NZ_CP077649:c4517091-4516820 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References