Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4524331..4525112 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q87_RS22120 Protein ID WP_000626100.1
Coordinates 4524331..4524822 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q87_RS22125 Protein ID WP_001110452.1
Coordinates 4524819..4525112 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS22085 (4519791) 4519791..4520138 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
H9Q87_RS22090 (4520114) 4520114..4521817 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q87_RS22095 (4521854) 4521854..4522429 + 576 WP_001188509.1 transcriptional regulator -
H9Q87_RS22105 (4522700) 4522700..4522774 - 75 Protein_4303 helix-turn-helix domain-containing protein -
H9Q87_RS22110 (4523154) 4523154..4523231 + 78 Protein_4304 porin family protein -
H9Q87_RS22115 (4523331) 4523331..4524083 + 753 WP_000842433.1 non-specific acid phosphatase -
H9Q87_RS22120 (4524331) 4524331..4524822 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q87_RS22125 (4524819) 4524819..4525112 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q87_RS22130 (4525429) 4525429..4525650 + 222 WP_001576552.1 hypothetical protein -
H9Q87_RS22135 (4525916) 4525916..4526791 + 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q87_RS22140 (4526788) 4526788..4527075 + 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q87_RS22145 (4527068) 4527068..4527376 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
H9Q87_RS22150 (4527375) 4527375..4527623 + 249 Protein_4312 Ig-like domain-containing protein -
H9Q87_RS22155 (4527735) 4527735..4527866 + 132 Protein_4313 hypothetical protein -
H9Q87_RS22160 (4528160) 4528160..4529065 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170590 WP_000626100.1 NZ_CP060668:c4524822-4524331 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170590 NZ_CP077649:2795083-2795313 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170590 WP_001110452.1 NZ_CP060668:c4525112-4524819 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170590 NZ_CP077649:2795310-2795669 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References