Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4417435..4417951 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag H9Q87_RS21545 Protein ID WP_000220582.1
Coordinates 4417435..4417719 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag H9Q87_RS21550 Protein ID WP_000212724.1
Coordinates 4417709..4417951 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS21530 (4412646) 4412646..4414298 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
H9Q87_RS21535 (4414707) 4414707..4416845 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
H9Q87_RS21540 (4416967) 4416967..4417431 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H9Q87_RS21545 (4417435) 4417435..4417719 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9Q87_RS21550 (4417709) 4417709..4417951 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H9Q87_RS21555 (4418029) 4418029..4419942 - 1914 WP_001212142.1 BglG family transcription antiterminator -
H9Q87_RS21560 (4419959) 4419959..4420699 - 741 WP_000779259.1 KDGP aldolase family protein -
H9Q87_RS21565 (4420696) 4420696..4421814 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
H9Q87_RS21570 (4421798) 4421798..4422931 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T170589 WP_000220582.1 NZ_CP060668:c4417719-4417435 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T170589 NZ_CP077649:c2327052-2326741 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT170589 WP_000212724.1 NZ_CP060668:c4417951-4417709 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT170589 NZ_CP077649:c2326740-2326450 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References