Detailed information of TA system TA170528

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1731686..1732298
• Replicon: chromosome
• Accession: NZ_CP060639
• Organism: Streptococcus pyogenes strain TSPY153

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H7797_RS08740
• Protein ID: WP_014635711.1
• Coordinates: 1731963..1732298 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: H7797_RS08735
• Protein ID: WP_002988079.1
• Coordinates: 1731686..1731973 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7797_RS08710 (H7797_08685)	1726876..1727859	-	984	WP_111693403.1	tagatose-bisphosphate aldolase	-
H7797_RS08715 (H7797_08690)	1727863..1728792	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
H7797_RS08720 (H7797_08695)	1728838..1729353	-	516	WP_023612880.1	galactose-6-phosphate isomerase subunit LacB	-
H7797_RS08725 (H7797_08700)	1729388..1729816	-	429	WP_111693404.1	galactose-6-phosphate isomerase subunit LacA	-
H7797_RS08730 (H7797_08705)	1730263..1731036	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
H7797_RS08735 (H7797_08710)	1731686..1731973	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
H7797_RS08740 (H7797_08715)	1731963..1732298	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7797_RS08745	1732395..1733431	+	1037	Protein_1671	site-specific integrase	-
H7797_RS08750 (H7797_08730)	1733551..1733943	-	393	WP_002982716.1	30S ribosomal protein S9	-
H7797_RS08755 (H7797_08735)	1733964..1734410	-	447	WP_002982710.1	50S ribosomal protein L13	-
H7797_RS08760 (H7797_08740)	1734628..1734834	-	207	WP_111693406.1	helix-turn-helix transcriptional regulator	-
H7797_RS08765 (H7797_08745)	1734831..1735529	-	699	WP_161230228.1	hypothetical protein	-
H7797_RS08770 (H7797_08750)	1735665..1736525	-	861	WP_011529009.1	DegV family protein	-
H7797_RS08775 (H7797_08755)	1736622..1737140	-	519	WP_111693408.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T170528 WP_014635711.1 NZ_CP060639:1731963-1732298 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T170528 NZ_CP077423:c1629903-1629571 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGGATTATAAGAAGTACAAGCTTATCTATTCTCAAAGGGTCATTGACACGCTTGATGATATTTATCATTATATTGCTAA
TGAAATAGGCTCAACAATTAACGCTAAAAAGAAAATTGCAAGTATTAGGAAAGATTTACAACGCTTGGAGTTTTTTCCAG
AGGGTGGTTTTGATGCTGATGAAAAATTTGGAAAGTGTCTGGATCCCAAGTATAAAACAAGAGGTTTAACGTTGAGTAAG
GACTATATTGCCTTGTATAATATTTTGGAAAATGAGGTTCGTATAGCATATTTGTTACCTACTCGCAGTGACTATATGGA
TTTATTTAGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT170528 WP_002988079.1 NZ_CP060639:1731686-1731973 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT170528 NZ_CP077423:c1630177-1629893 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGGCTTTAGCTTATGATAAAAGTTACAATTTAAGAACTTATCAAAAAATTTATAATCAAGCAGAAAAAGTATTTAAGGA
AAATAATTTAAATACCGCTCAGGCTTTAAATTTATTTCTAAAAAATGTTGCTGAAACAGGTCAACTTAATTTGAAAACAG
AAGAAGAACTTAAAAGAGAAAAGTTGTTTAAAAATCTTCAAGCAGAGATTCAACAAAGTTATGCTGAATTTGATGAAGGG
AAATTTTATACTGATGAGGATTTGGTAGAACGCTATGGATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94