Detailed information of TA system TA170447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 99676..100220
• Replicon: chromosome
• Accession: NZ_CP060470
• Organism: Xanthomonas citri pv. citri strain DAR73889

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8FI26
• Locus tag: H8Z72_RS00430
• Protein ID: WP_003487886.1
• Coordinates: 99921..100220 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: H8Z72_RS00425
• Protein ID: WP_003487884.1
• Coordinates: 99676..99933 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8Z72_RS00410	94777..96276	-	1500	WP_040237593.1	ribonuclease H-like domain-containing protein	-
H8Z72_RS00415	96273..98768	-	2496	WP_015462699.1	DEAD/DEAH box helicase	-
H8Z72_RS00420	98946..99608	+	663	WP_005912558.1	hemolysin III family protein	-
H8Z72_RS00425	99676..99933	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H8Z72_RS00430	99921..100220	+	300	WP_003487886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H8Z72_RS00440	100400..101299	-	900	WP_011050073.1	SDR family NAD(P)-dependent oxidoreductase	-
H8Z72_RS00445	101359..102096	-	738	WP_003487890.1	SDR family oxidoreductase	-
H8Z72_RS00450	102222..103133	+	912	WP_011050074.1	LysR family transcriptional regulator	-
H8Z72_RS00455	103299..104372	-	1074	WP_040107715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11231.97 Da
• Isoelectric Point: 9.7235

>T170447 WP_003487886.1 NZ_CP060470:99921-100220 [Xanthomonas citri pv. citri]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VVVHVMRSERALRGNRLSR

Nucleotide

• Length: 300 bp

>T170447 NZ_CP077388:c21806-21498 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAATCGAGAAAATACAGTCAAACACCCATATTTACTGGACATTCAAAGTAATATTATTGA
TATATTGAATACTCTTTTAGTCATCCCGTTATTCGATAGCAGGCTAGCTAAAAAACCATTACCTACTTGCCTTAACCCCC
AGTTATTTAGCAACGGGCAGGTGTTTGTTTTAATGACACACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTGAACTGCCAACAAAACACGATTAAACACGCAATTGACTTACTTATTGATGGCTTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT170447 WP_003487884.1 NZ_CP060470:99676-99933 [Xanthomonas citri pv. citri]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT170447 NZ_CP077388:c22006-21806 [Providencia rettgeri]
ATCACTGTAGCGCCTGAGCTCTGCGAACAAGCAAGGCGGGCTAAACTCAACTTATCTGCAATACTAACTTGTGCCTTACA
AGCTGAATTAAAACGCCTAGAAGCACAAAAGTGGAAAAATGAAAATATCGAAGGTTTTAATCAATTAAATAGGAACAATG
AAGAATACGGATTACTCTCAGATAAATACAAGGGTTTTTAA

Structures

Toxin

• AlphaFold DB: H8FI26

Antitoxin

• AlphaFold DB: H8FI25