Detailed information of TA system TA170209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 943026..943623
• Replicon: chromosome
• Accession: NZ_CP060280
• Organism: Neisseria meningitidis strain LNP24198

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: H7969_RS04835
• Protein ID: WP_002242826.1
• Coordinates: 943026..943304 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H7969_RS04840
• Protein ID: WP_002221020.1
• Coordinates: 943312..943623 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7969_RS04800	938468..939139	+	672	WP_002217215.1	CsgG/HfaB family protein	-
H7969_RS04805	939149..939517	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
H7969_RS04810	939514..940161	+	648	WP_002217218.1	DUF799 domain-containing protein	-
H7969_RS04815	940603..941745	+	1143	WP_002221015.1	ABC transporter ATP-binding protein/permease	-
H7969_RS04820	941855..942064	-	210	WP_002221016.1	hypothetical protein	-
H7969_RS04825	942061..942357	-	297	WP_002221017.1	hypothetical protein	-
H7969_RS04830	942336..942941	-	606	WP_002219301.1	hypothetical protein	-
H7969_RS04835	943026..943304	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7969_RS04840	943312..943623	+	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
H7969_RS04845	944452..946425	-	1974	WP_002221022.1	pyocin knob domain-containing protein	-
H7969_RS04850	946436..946996	-	561	WP_002213590.1	YmfQ family protein	-
H7969_RS04855	946993..947604	-	612	WP_002224558.1	baseplate J/gp47 family protein	-
H7969_RS04860	947604..947768	-	165	WP_002224559.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	923029..955666	32637
	-	flank	IS/Tn	-	-	947833..948798	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T170209 WP_002242826.1 NZ_CP060280:943026-943304 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T170209 NZ_CP077198:625364-625651 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGATCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT170209 WP_002221020.1 NZ_CP060280:943312-943623 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT170209 NZ_CP077198:625086-625367 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAT
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6