Detailed information of TA system TA170158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1263649..1264174
• Replicon: chromosome
• Accession: NZ_CP060264
• Organism: Aliarcobacter cryaerophilus strain 16CS0369-1-AR-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HOO31_RS06455
• Protein ID: WP_120987012.1
• Coordinates: 1263649..1263933 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A494T8Z2
• Locus tag: HOO31_RS06460
• Protein ID: WP_066402160.1
• Coordinates: 1263917..1264174 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOO31_RS06435	1258918..1260648	-	1731	WP_186984310.1	UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)	-
HOO31_RS06440	1260654..1261244	-	591	WP_186984311.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
HOO31_RS06445	1261266..1262690	-	1425	WP_186984312.1	putative DNA binding domain-containing protein	-
HOO31_RS06450	1262690..1263652	-	963	WP_186984313.1	glycosyltransferase family 4 protein	-
HOO31_RS06455	1263649..1263933	-	285	WP_120987012.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HOO31_RS06460	1263917..1264174	-	258	WP_066402160.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HOO31_RS06465	1264387..1265241	-	855	WP_186984314.1	NAD-dependent epimerase/dehydratase family protein	-
HOO31_RS06470	1265238..1266362	-	1125	WP_186984315.1	glycosyltransferase	-
HOO31_RS06475	1266381..1267607	-	1227	WP_186984316.1	hypothetical protein	-
HOO31_RS06480	1267585..1268682	-	1098	WP_186984317.1	glycosyltransferase family 4 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11320.20 Da
• Isoelectric Point: 10.3690

>T170158 WP_120987012.1 NZ_CP060264:c1263933-1263649 [Aliarcobacter cryaerophilus]
MSYFLDFHPKALKEWKNLNQSLKIQFHKKLKERLENPRVSKDKLSGYENIYKIKLRSSGFRLAYEVKDLEIIVYVVSVGK
RENNKVYENLKDRI

Nucleotide

• Length: 285 bp

>T170158 NZ_CP077092:1940146-1940358 [Pseudomonas iranensis]
GTGCAGAGCAGGCTATTGATGAACGAGCTGGAGGAGGCGGACTGGACGCTGGATCGGGTTGCGGGCAGTCATCACATCTT
CACTCATCGTTACAACCCGAACACGATTGCCGTCCCGCATCCGAAAAAGGATTTACCGCTGGCGACAGTCAAAAGCATTC
GGCGGCGCGCGGGGTTATTCAGCCCGCCAACCCGACATGAAGGAGATCCGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9673.10 Da
• Isoelectric Point: 4.2696

>AT170158 WP_066402160.1 NZ_CP060264:c1264174-1263917 [Aliarcobacter cryaerophilus]
MQPILANYTASITELKKSPTQLLKDAGDEAIAILNHNVASAYLVPASLYEKMMEVMDDYYLSKELEERLKDNEKPIRVEL
DELLS

Nucleotide

• Length: 258 bp

>AT170158 NZ_CP077092:1940358-1940762 [Pseudomonas iranensis]
ATGCAATATCCCATCTGCATCGAGTGGGGTGACGAGAACACTGCCATCGGCATTCAGATCCCCGATATTCCCGGCGCGGT
CACGGCCGGGGACAGCTTTGAAGAGGCCTACAACGCGGCCGTGGAAGTGGCTCACCTCATGCTGCAGGAGATCGCGGCGG
CCGGTCAGGCGATTCCGATGCCGACCTCGGCAGCGGCGCATCGCAATCGTCCGGATTTTGCCAAGATGGGCTGGGGCATG
CTGGAGCTGGATATCTCGCCGTACCTGGGCAAGACCGAAAAGGTCAACGTTACGCTGCCCGGCTATGTCATTCAGCGTAT
TGATCGCTATGTACGCGAGCACAACGTCAAAAGCCGCTCCTCGTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGGT
ATTGA

Structures

Antitoxin

• AlphaFold DB: A0A494T8Z2