Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1113085..1113590 Replicon chromosome
Accession NZ_CP060264
Organism Aliarcobacter cryaerophilus strain 16CS0369-1-AR-4

Toxin (Protein)


Gene name yoeB Uniprot ID A0A494T483
Locus tag HOO31_RS05695 Protein ID WP_066157207.1
Coordinates 1113324..1113590 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1V9VC04
Locus tag HOO31_RS05690 Protein ID WP_066157209.1
Coordinates 1113085..1113330 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOO31_RS05660 1108153..1108745 + 593 Protein_1100 DUF45 domain-containing protein -
HOO31_RS05665 1108747..1109187 - 441 WP_186984213.1 DUF721 domain-containing protein -
HOO31_RS05670 1109158..1109295 + 138 WP_186985322.1 hypothetical protein -
HOO31_RS05675 1109292..1110743 + 1452 WP_186984214.1 FAD-binding protein -
HOO31_RS05680 1110797..1112332 + 1536 WP_186984215.1 glutamine-hydrolyzing GMP synthase -
HOO31_RS05685 1112571..1112846 + 276 WP_208994075.1 HNH endonuclease -
HOO31_RS05690 1113085..1113330 + 246 WP_066157209.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HOO31_RS05695 1113324..1113590 + 267 WP_066157207.1 Txe/YoeB family addiction module toxin Toxin
HOO31_RS05700 1113600..1115303 - 1704 WP_186984216.1 YdiU family protein -
HOO31_RS05705 1115466..1116764 + 1299 WP_186984217.1 succinylglutamate desuccinylase/aspartoacylase family protein -
HOO31_RS05710 1116789..1116983 - 195 WP_186984218.1 DUF2892 domain-containing protein -
HOO31_RS05715 1117144..1117848 + 705 WP_186984219.1 alpha/beta hydrolase -
HOO31_RS05720 1117902..1118495 + 594 WP_186984220.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(24-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10229.96 Da        Isoelectric Point: 9.9946

>T170157 WP_066157207.1 NZ_CP060264:1113324-1113590 [Aliarcobacter cryaerophilus]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISLNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Download         Length: 267 bp

>T170157 NZ_CP077092:c1103930-1103679 [Pseudomonas iranensis]
ATGTCAAAGACTGAAAAACTTCTCGCCAAACTAGTCAACGGCCGAAGCGCATTCACATGGTCCGAGCTTGTCACTCTGTT
GGCGCGTCTTGGTTACTCTCAGCTGGAAGGATCCGGTAGCAGGATCAAATTCGACAACGGGAATCCGAGCGCATTGATCA
ACCTGCACAAGCCACATCCCGGAAATGAAATCAAAACATACGCAAGACGCCAGATTATCGAGCAACTGAAAACAGGAGGC
CTGATTCCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9284.61 Da        Isoelectric Point: 4.2550

>AT170157 WP_066157209.1 NZ_CP060264:1113085-1113330 [Aliarcobacter cryaerophilus]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDKELE
W

Download         Length: 246 bp

>AT170157 NZ_CP077092:c1103682-1103341 [Pseudomonas iranensis]
ATGAGTTCCCAGCTGCACTACAAAGGCTATGTTGGCTCTATCGAGGCGAGCACGGAAGACAAGTGCCTGTTCGGAAAACT
CCTTTTCATCAGGGCGCTGGTTAATTATGAAGGACAAACGGTGGCTGAACTGGAAGCAGCCTTTCGCGAGGCGGTAGATG
ACTATTTACAAACCTGTGAGCAGCTCGGGCAGAAGCCTGAAATCCCATGCAAAGGATCGTTCAATGTTCGCATCGGTCAC
GATCTGCATTTAGCAGCGGCTCTGGCGGCAACCCGTCAAAATGTGTCGTTGAATGATCTGACACGTCAAGCACTGAACGA
ATACCTCCAACACCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A494T483

Antitoxin

Source ID Structure
AlphaFold DB A0A1V9VC04

References