Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2486992..2487603 Replicon chromosome
Accession NZ_CP060159
Organism Xylella fastidiosa subsp. fastidiosa strain GV230

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag XFGV230_RS10960 Protein ID WP_011098375.1
Coordinates 2487304..2487603 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag XFGV230_RS10955 Protein ID WP_004085003.1
Coordinates 2486992..2487300 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFGV230_RS10925 2483562..2484323 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
XFGV230_RS10950 2485515..2486918 + 1404 WP_011098374.1 hypothetical protein -
XFGV230_RS10955 2486992..2487300 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
XFGV230_RS10960 2487304..2487603 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFGV230_RS10965 2487691..2488235 + 545 Protein_2133 hypothetical protein -
XFGV230_RS10970 2488247..2488390 + 144 WP_155115087.1 hypothetical protein -
XFGV230_RS10975 2488543..2488923 - 381 WP_004089371.1 DUF596 domain-containing protein -
XFGV230_RS10980 2488928..2490058 - 1131 WP_012382788.1 DUF769 domain-containing protein -
XFGV230_RS10985 2490366..2490746 - 381 WP_004087391.1 DUF596 domain-containing protein -
XFGV230_RS10990 2490758..2492332 - 1575 Protein_2138 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2440493..2496992 56499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T170079 WP_011098375.1 NZ_CP060159:c2487603-2487304 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T170079 NZ_CP077079:c2793256-2793005 [Pseudomonas asgharzadehiana]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAATTGCTCAATGAACAAACGTTATTTACCTGGCCCGAATGGGTCACGCTATT
GCGACGGCTGGGCTACACACAGATTGAAGGGGCTGGAAGCCGCGTCAAGTTCGACATCGGCAACCCCAGTGCAATGATCA
CCTTGCACAGGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACACTTGCGATCAGGAGAA
CTGATTCCGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT170079 WP_004085003.1 NZ_CP060159:c2487300-2486992 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT170079 NZ_CP077079:c2793008-2792643 [Pseudomonas asgharzadehiana]
GTGAACAACCAACTCAAATACAAAGGCTACATAGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
TCTGTTCATCAAGGCTTTGGTCAGCTATGAAGGCAAAACCGTCGCCGAACTGGACGCGGCGTTTCACGAGGCGGTGGATG
ACTACCTCGCGACGTGCCAGTCGCTGGGGCAAACCCCGGAGAAACCTTGCAAAGGCTCGTTCAACGTGCGCGTCGGCCAT
GAACTGCATCTGGCTGCGGCCCTGGCCGCGGCACGAAAAAAAGTCACGCTCAACGACCTGACCCGTCAGGCGCTGAACGA
ATTCCTGCACCATCACAGCGCGGATGCAGGCCCGGCGATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References