Detailed information of TA system TA169947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 688339..690167
• Replicon: chromosome
• Accession: NZ_CP060088
• Organism: Vibrio parahaemolyticus strain TJA114

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: H5404_RS11185
• Protein ID: WP_185215330.1
• Coordinates: 688806..690167 (-)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H5404_RS11180
• Protein ID: WP_029786578.1
• Coordinates: 688339..688821 (-)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5404_RS11170	684986..686524	+	1539	WP_089204573.1	DNA cytosine methyltransferase	-
H5404_RS11175	686730..687865	-	1136	Protein_606	tyrosine-type recombinase/integrase	-
H5404_RS11180	688339..688821	-	483	WP_029786578.1	helix-turn-helix domain-containing protein	Antitoxin
H5404_RS11185	688806..690167	-	1362	WP_185215330.1	type II toxin-antitoxin system HipA family toxin	Toxin
H5404_RS11190	690647..691438	-	792	WP_159408111.1	metallophosphoesterase	-
H5404_RS11195	691686..691976	+	291	Protein_610	hypothetical protein	-
H5404_RS11200	692059..692445	-	387	WP_159408110.1	transcriptional regulator	-
H5404_RS11205	693066..693980	+	915	WP_159408108.1	hypothetical protein	-
H5404_RS11210	693970..694389	+	420	WP_161613064.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	663452..716748	53296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-139)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51311.01 Da
• Isoelectric Point: 4.8126

>T169947 WP_185215330.1 NZ_CP060088:c690167-688806 [Vibrio parahaemolyticus]
MEELTVQAFLRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLTFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRVKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVSLDHEATIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCLNLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T169947 NZ_CP076809:4524-4844 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17535.05 Da
• Isoelectric Point: 10.8446

>AT169947 WP_029786578.1 NZ_CP060088:c688821-688339 [Vibrio parahaemolyticus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Nucleotide

• Length: 483 bp

>AT169947 NZ_CP076809:4837-5109 [Acinetobacter baumannii]
ATGGATAACAACTTATTAGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA