Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1840624..1841456 | Replicon | chromosome |
| Accession | NZ_CP060065 | ||
| Organism | Escherichia coli strain G5 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | H4P49_RS08750 | Protein ID | WP_000854765.1 |
| Coordinates | 1840624..1840998 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | H4P49_RS08755 | Protein ID | WP_187002603.1 |
| Coordinates | 1841088..1841456 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4P49_RS08715 | 1836083..1836412 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| H4P49_RS08720 | 1836513..1836695 | - | 183 | WP_001667686.1 | ethanolamine utilization - propanediol utilization family protein | - |
| H4P49_RS08725 | 1836969..1837748 | - | 780 | WP_001297096.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| H4P49_RS08730 | 1837748..1838770 | - | 1023 | WP_000255946.1 | IS21-like element IS100 family transposase | - |
| H4P49_RS08735 | 1839108..1840136 | - | 1029 | Protein_1706 | IS110 family transposase | - |
| H4P49_RS08740 | 1840295..1840408 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| H4P49_RS08745 | 1840421..1840627 | - | 207 | WP_000976829.1 | hypothetical protein | - |
| H4P49_RS08750 | 1840624..1840998 | - | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| H4P49_RS08755 | 1841088..1841456 | - | 369 | WP_187002603.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H4P49_RS08760 | 1841619..1841840 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| H4P49_RS08765 | 1841903..1842379 | - | 477 | WP_001186789.1 | RadC family protein | - |
| H4P49_RS08770 | 1842395..1842868 | - | 474 | WP_000855064.1 | antirestriction protein | - |
| H4P49_RS08775 | 1843210..1844028 | - | 819 | WP_001234729.1 | DUF945 domain-containing protein | - |
| H4P49_RS08780 | 1844297..1844722 | + | 426 | WP_000422741.1 | IS66 family insertion sequence hypothetical protein | - |
| H4P49_RS08785 | 1844719..1845069 | + | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| H4P49_RS08790 | 1845276..1846022 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1836969..1894817 | 57848 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T169840 WP_000854765.1 NZ_CP060065:c1840998-1840624 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T169840 NZ_CP076704:1042281-1042616 [Escherichia coli O8:H28]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13576.35 Da Isoelectric Point: 6.6255
>AT169840 WP_187002603.1 NZ_CP060065:c1841456-1841088 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTPGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTPGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT169840 NZ_CP076704:1042033-1042281 [Escherichia coli O8:H28]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|