Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1441225..1441748 Replicon chromosome
Accession NZ_CP060040
Organism Burkholderia cenocepacia strain PS27

Toxin (Protein)


Gene name relE Uniprot ID A0A7G6V603
Locus tag SY91_RS22925 Protein ID WP_006480834.1
Coordinates 1441482..1441748 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1K8I6
Locus tag SY91_RS22920 Protein ID WP_011547275.1
Coordinates 1441225..1441485 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SY91_RS22890 1436595..1437803 - 1209 WP_023476059.1 acetate/propionate family kinase -
SY91_RS22895 1437814..1438785 - 972 WP_006480840.1 phosphate acetyltransferase -
SY91_RS22900 1438933..1439808 + 876 WP_043887462.1 ATP synthase F1 subunit gamma -
SY91_RS22905 1439819..1440277 + 459 WP_023476056.1 ATP synthase F1 subunit epsilon -
SY91_RS22910 1440300..1440518 - 219 WP_006480837.1 DUF1653 domain-containing protein -
SY91_RS22915 1440576..1441019 - 444 WP_023476055.1 GNAT family N-acetyltransferase -
SY91_RS22920 1441225..1441485 + 261 WP_011547275.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SY91_RS22925 1441482..1441748 + 267 WP_006480834.1 Txe/YoeB family addiction module toxin Toxin
SY91_RS22930 1441798..1442421 + 624 WP_006480833.1 HAD hydrolase-like protein -
SY91_RS22935 1442837..1443415 + 579 WP_006480832.1 DUF4142 domain-containing protein -
SY91_RS22940 1443532..1444131 - 600 WP_023476053.1 GNAT family N-acetyltransferase -
SY91_RS22945 1444191..1445105 - 915 WP_011547270.1 LysR family transcriptional regulator -
SY91_RS22950 1445214..1446452 + 1239 WP_023476052.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10556.88 Da        Isoelectric Point: 7.9861

>T169739 WP_006480834.1 NZ_CP060040:1441482-1441748 [Burkholderia cenocepacia]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQLSI
VSCRYHYE

Download         Length: 267 bp

>T169739 NZ_CP076687:c3552619-3552305 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9745.00 Da        Isoelectric Point: 6.0717

>AT169739 WP_011547275.1 NZ_CP060040:1441225-1441485 [Burkholderia cenocepacia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Download         Length: 261 bp

>AT169739 NZ_CP076687:c3552308-3551892 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V603

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9NJ62

References