Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3720049..3720689 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5T25_RS17190 Protein ID WP_083010951.1
Coordinates 3720049..3720468 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5T25_RS17195 Protein ID WP_083010950.1
Coordinates 3720465..3720689 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS17170 (H5T25_17030) 3715112..3716302 - 1191 WP_139797018.1 hypothetical protein -
H5T25_RS24990 3717457..3717582 + 126 WP_254893611.1 hypothetical protein -
H5T25_RS17175 (H5T25_17035) 3717940..3718332 + 393 WP_083010953.1 hypothetical protein -
H5T25_RS17180 (H5T25_17040) 3718333..3719082 + 750 WP_139797017.1 RES domain-containing protein -
H5T25_RS17185 (H5T25_17045) 3719218..3719814 - 597 WP_071510131.1 winged helix-turn-helix domain-containing protein -
H5T25_RS17190 (H5T25_17050) 3720049..3720468 - 420 WP_083010951.1 type II toxin-antitoxin system VapC family toxin Toxin
H5T25_RS17195 (H5T25_17055) 3720465..3720689 - 225 WP_083010950.1 antitoxin Antitoxin
H5T25_RS17200 (H5T25_17060) 3721218..3722399 - 1182 WP_139797016.1 hypothetical protein -
H5T25_RS17205 (H5T25_17065) 3722876..3723160 - 285 WP_083010948.1 DUF1876 family protein -
H5T25_RS17210 (H5T25_17070) 3723299..3724126 - 828 WP_083010947.1 SDR family NAD(P)-dependent oxidoreductase -
H5T25_RS17215 (H5T25_17075) 3724236..3725456 - 1221 WP_083010997.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14855.89 Da        Isoelectric Point: 7.1290

>T169705 WP_083010951.1 NZ_CP060015:c3720468-3720049 [Mycobacterium malmoense]
VTALLDVNVLIALSWRNHAHHSAARQWFTRSSSNGWATTPITEVGFVRISSDRRVMHVSTTPATALAQLEALRALPGHAF
WPDDVPLVVGEGGDRGAVSSHRLVTDCHLIALVARYGGRLVTFDAALADSAPAGLVEVL

Download         Length: 420 bp

>T169705 NZ_CP076670:24802-25077 [Listeria monocytogenes]
ATGAGTAAACATTTTCATGTGAGATTTGAGAAAGATGCTCAAAAAGTATTAAAAAAGATGGATCGATTTCAAGCGAAATT
GATTTTATCTTGGATTGAAAAGCATATCGAAGGATCAGATAATCCACGTCAACATGGTAAAAGCTTAGTTGGCAATCGTG
TAGGACAGTGGAGATATAGAGTAGGAGATTATCGCTTAATTGCAGAGATTCAAGATAATGAAGTGATAGTGTTAATTTTG
AACATCGGACACAGGAGAGATATTTACGATAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7986.02 Da        Isoelectric Point: 3.9937

>AT169705 WP_083010950.1 NZ_CP060015:c3720689-3720465 [Mycobacterium malmoense]
MRTTLQIDDDILEDARSIARSEGRSVGAVISDLARRSLRPVGIVVVDGLPMFDVPPDAPIIADEDVARGLEEDV

Download         Length: 225 bp

>AT169705 NZ_CP076670:24584-24805 [Listeria monocytogenes]
ATGACTACCATTACATTTCGAGTATCTGAACAAGAAAAGGCGTTTATTCAAGAAATGGCTAAGTTTAATGGTATATCTAT
TTCTGAACTCAGTCGCAAACAGATTATAGAAGGTTTAGAAGATCAAATTGATTTACAATCGTATGAGCGTGCTATAAAGG
CGCATCAGGTGAAGGATGAAAGTATTTCTTTTGATGAAATGAAAAAGGAACTTGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References