Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 58976..59469 Replicon plasmid pB2_V3
Accession NZ_CP060001
Organism Xanthomonas citri pv. citri strain B2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HZS92_RS23030 Protein ID WP_015462614.1
Coordinates 58976..59302 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HZS92_RS23035 Protein ID WP_017157755.1
Coordinates 59299..59469 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS92_RS23020 (HZS92_07070) 54359..55933 + 1575 WP_011052977.1 type IV secretion system DNA-binding domain-containing protein -
HZS92_RS23025 (HZS92_07071) 55947..58922 + 2976 WP_045715643.1 MobF family relaxase -
HZS92_RS23030 (HZS92_07072) 58976..59302 - 327 WP_015462614.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HZS92_RS23035 (HZS92_07073) 59299..59469 - 171 WP_017157755.1 antitoxin MazE family protein Antitoxin
HZS92_RS23040 (HZS92_07074) 59654..60040 - 387 WP_003491149.1 hypothetical protein -
HZS92_RS23045 (HZS92_07075) 60117..60536 - 420 WP_011052981.1 hypothetical protein -
HZS92_RS23050 (HZS92_07076) 60662..61540 - 879 WP_011052982.1 lytic transglycosylase domain-containing protein -
HZS92_RS23055 (HZS92_07077) 61551..62573 - 1023 WP_011052983.1 P-type DNA transfer ATPase VirB11 -
HZS92_RS23060 (HZS92_07078) 62584..63804 - 1221 WP_011052984.1 TrbI/VirB10 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94653 94653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11676.70 Da        Isoelectric Point: 9.2550

>T169673 WP_015462614.1 NZ_CP060001:c59302-58976 [Xanthomonas citri pv. citri]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T169673 NZ_CP076654:1393876-1394274 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6518.34 Da        Isoelectric Point: 4.1476

>AT169673 WP_017157755.1 NZ_CP060001:c59469-59299 [Xanthomonas citri pv. citri]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT169673 NZ_CP076654:1393649-1393876 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References