Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 78989..79482 Replicon plasmid pB2_V1
Accession NZ_CP060000
Organism Xanthomonas citri pv. citri strain B2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HZS92_RS22350 Protein ID WP_015462614.1
Coordinates 78989..79315 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HZS92_RS22355 Protein ID WP_017157755.1
Coordinates 79312..79482 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS92_RS22340 (HZS92_06102) 74372..75946 + 1575 WP_011052977.1 type IV secretion system DNA-binding domain-containing protein -
HZS92_RS22345 (HZS92_06103) 75960..78935 + 2976 WP_045715643.1 MobF family relaxase -
HZS92_RS22350 (HZS92_06104) 78989..79315 - 327 WP_015462614.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HZS92_RS22355 (HZS92_06105) 79312..79482 - 171 WP_017157755.1 antitoxin MazE family protein Antitoxin
HZS92_RS22360 (HZS92_06106) 79667..80053 - 387 WP_003491149.1 hypothetical protein -
HZS92_RS22365 (HZS92_06107) 80130..80549 - 420 WP_011052981.1 hypothetical protein -
HZS92_RS22370 (HZS92_06108) 80675..81553 - 879 WP_011052982.1 lytic transglycosylase domain-containing protein -
HZS92_RS22375 (HZS92_06109) 81564..82586 - 1023 WP_011052983.1 P-type DNA transfer ATPase VirB11 -
HZS92_RS22380 (HZS92_06110) 82597..83817 - 1221 WP_011052984.1 TrbI/VirB10 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..137420 137420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(2-54)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11676.70 Da        Isoelectric Point: 9.2550

>T169670 WP_015462614.1 NZ_CP060000:c79315-78989 [Xanthomonas citri pv. citri]
MMRGDFVTIAMQGDFGKPRPALVIQADQFDAHTTVTVLPVTSTLVAAPLLRITVHPSTDNGLQKPSQVMVDKAMTVKRDK
VGRAFGRVDADALVEIERCLAVFLGIAK

Download         Length: 327 bp

>T169670 NZ_CP076654:949714-950121 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6518.34 Da        Isoelectric Point: 4.1476

>AT169670 WP_017157755.1 NZ_CP060000:c79482-79312 [Xanthomonas citri pv. citri]
MAGLRPVQIWVPDTRRPDFAEECRRQCRLAAQADMADTDMQRFMDEALADMDGWTE

Download         Length: 171 bp

>AT169670 NZ_CP076654:949467-949733 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References