Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5046487..5047154 Replicon chromosome
Accession NZ_CP059999
Organism Xanthomonas citri pv. citri strain B2

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag HZS92_RS21605 Protein ID WP_005916679.1
Coordinates 5046738..5047154 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag HZS92_RS21600 Protein ID WP_005916676.1
Coordinates 5046487..5046741 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS92_RS21575 5042649..5042828 + 180 WP_011052886.1 RNA 2'-phosphotransferase -
HZS92_RS21580 (HZS92_04573) 5042985..5044250 + 1266 WP_015463799.1 phospholipase D-like domain-containing protein -
HZS92_RS21585 (HZS92_04574) 5044276..5044803 - 528 WP_005916668.1 hypothetical protein -
HZS92_RS21590 (HZS92_04575) 5045042..5045248 + 207 WP_003489327.1 hypothetical protein -
HZS92_RS21595 (HZS92_04576) 5045235..5046341 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZS92_RS21600 (HZS92_04577) 5046487..5046741 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
HZS92_RS21605 (HZS92_04578) 5046738..5047154 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
HZS92_RS21610 (HZS92_04579) 5047276..5047488 - 213 WP_149029621.1 hypothetical protein -
HZS92_RS21615 (HZS92_04580) 5047607..5047819 - 213 WP_015472901.1 hypothetical protein -
HZS92_RS21620 (HZS92_04581) 5048076..5049695 + 1620 WP_015463800.1 alpha/beta hydrolase-fold protein -
HZS92_RS21625 (HZS92_04582) 5049799..5050197 - 399 WP_004429277.1 DUF2384 domain-containing protein -
HZS92_RS21630 (HZS92_04583) 5050513..5050944 + 432 WP_005922907.1 hypothetical protein -
HZS92_RS21635 5050973..5051203 - 231 WP_223293191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T169667 WP_005916679.1 NZ_CP059999:5046738-5047154 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T169667 NZ_CP076654:c599999-599535 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT169667 WP_005916676.1 NZ_CP059999:5046487-5046741 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT169667 NZ_CP076654:c600334-599999 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References