Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144150..144655 Replicon chromosome
Accession NZ_CP059995
Organism Pseudomonas aeruginosa strain 401853

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag H5J27_RS00660 Protein ID WP_003083773.1
Coordinates 144150..144431 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag H5J27_RS00665 Protein ID WP_003083775.1
Coordinates 144428..144655 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5J27_RS00635 139401..140750 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
H5J27_RS00640 140799..141485 + 687 WP_003083762.1 FadR family transcriptional regulator -
H5J27_RS00645 141586..142320 + 735 WP_003117208.1 GntR family transcriptional regulator -
H5J27_RS00650 142524..142910 + 387 WP_014602345.1 aegerolysin family protein -
H5J27_RS00655 142942..143850 - 909 WP_010793581.1 LysR family transcriptional regulator -
H5J27_RS00660 144150..144431 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
H5J27_RS00665 144428..144655 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
H5J27_RS00670 144831..145451 - 621 WP_003101226.1 hypothetical protein -
H5J27_RS00675 145552..146052 + 501 WP_003101228.1 LEA type 2 family protein -
H5J27_RS00680 146125..146466 + 342 WP_003101229.1 alkylphosphonate utilization protein -
H5J27_RS00685 146548..147975 - 1428 WP_003083784.1 GABA permease -
H5J27_RS00690 148144..149637 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T169652 WP_003083773.1 NZ_CP059995:c144431-144150 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T169652 NZ_CP076651:798853-799197 [Serratia ureilytica]
ATGTGGCAAGTGGTGACCGTCGAACGATTCGACGACTGGTTTTTGGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAGGGAGTTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCTGCCATGGAATTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT169652 WP_003083775.1 NZ_CP059995:c144655-144428 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT169652 NZ_CP076651:799203-799505 [Serratia ureilytica]
ATGGCCAAACCGTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCACAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAACTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References