Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 921942..922568 Replicon chromosome
Accession NZ_CP059986
Organism Morganella morganii strain 11759

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag H4431_RS04310 Protein ID WP_024474604.1
Coordinates 921942..922145 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag H4431_RS04315 Protein ID WP_004236473.1
Coordinates 922209..922568 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4431_RS04290 (H4431_04290) 918498..918836 + 339 WP_004236467.1 P-II family nitrogen regulator -
H4431_RS04295 (H4431_04295) 918856..920145 + 1290 WP_036422539.1 ammonium transporter AmtB -
H4431_RS04300 (H4431_04300) 920206..921069 - 864 WP_062771844.1 acyl-CoA thioesterase II -
H4431_RS04310 (H4431_04310) 921942..922145 - 204 WP_024474604.1 HHA domain-containing protein Toxin
H4431_RS04315 (H4431_04315) 922209..922568 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
H4431_RS04320 (H4431_04320) 923131..926307 - 3177 WP_015422956.1 efflux RND transporter permease subunit -
H4431_RS04325 (H4431_04325) 926322..927518 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T169640 WP_024474604.1 NZ_CP059986:c922145-921942 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T169640 NZ_CP076646:2676929-2677036 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT169640 WP_004236473.1 NZ_CP059986:c922568-922209 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT169640 NZ_CP076646:c2676882-2676816 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References