Detailed information of TA system TA169639

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 814350..815029
• Replicon: chromosome
• Accession: NZ_CP059986
• Organism: Morganella morganii strain 11759

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: H4431_RS03760
• Protein ID: WP_160955866.1
• Coordinates: 814688..815029 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: H4431_RS03755
• Protein ID: WP_160955865.1
• Coordinates: 814350..814667 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4431_RS03710 (H4431_03710)	809908..810315	+	408	Protein_711	DUF932 domain-containing protein	-
H4431_RS03715 (H4431_03715)	810524..811234	+	711	WP_182095803.1	DeoR family transcriptional regulator	-
H4431_RS03720 (H4431_03720)	811260..811796	+	537	WP_160955859.1	DUF4339 domain-containing protein	-
H4431_RS03725 (H4431_03725)	811838..812275	+	438	WP_182095802.1	hypothetical protein	-
H4431_RS03730 (H4431_03730)	812342..812752	+	411	WP_182095801.1	hypothetical protein	-
H4431_RS03735 (H4431_03735)	812831..813067	+	237	Protein_716	DUF905 domain-containing protein	-
H4431_RS03740 (H4431_03740)	813153..813611	+	459	WP_182095800.1	antirestriction protein	-
H4431_RS03745 (H4431_03745)	813620..814102	+	483	WP_182095799.1	DNA repair protein RadC	-
H4431_RS03750 (H4431_03750)	814111..814332	+	222	WP_160955864.1	DUF987 domain-containing protein	-
H4431_RS03755 (H4431_03755)	814350..814667	+	318	WP_160955865.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H4431_RS03760 (H4431_03760)	814688..815029	+	342	WP_160955866.1	TA system toxin CbtA family protein	Toxin
H4431_RS03765 (H4431_03765)	815350..816276	-	927	WP_211671367.1	hypothetical protein	-
H4431_RS03770 (H4431_03770)	816273..817292	-	1020	WP_211671368.1	tyrosine-type recombinase/integrase	-
H4431_RS03775 (H4431_03775)	817296..818246	-	951	WP_211671369.1	hypothetical protein	-
H4431_RS03780 (H4431_03780)	818248..818835	-	588	WP_098935894.1	phage repressor protein CI	-
H4431_RS03785 (H4431_03785)	818974..819201	+	228	WP_211671370.1	regulator	-
H4431_RS03790 (H4431_03790)	819229..819726	+	498	WP_211671371.1	phage regulatory CII family protein	-
H4431_RS03795 (H4431_03795)	819734..819955	+	222	WP_211671372.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	805974..849328	43354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12899.80 Da
• Isoelectric Point: 8.0324

>T169639 WP_160955866.1 NZ_CP059986:814688-815029 [Morganella morganii]
MKTLPATTQQAAKLCLSPVAVWQMLLIRLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLFRRSRNNAVS

Nucleotide

• Length: 342 bp

>T169639 NZ_CP076646:2676394-2676501 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11844.47 Da
• Isoelectric Point: 6.8405

>AT169639 WP_160955865.1 NZ_CP059986:814350-814667 [Morganella morganii]
MSNTTWGLQRGITPRLGARLVQEGNRLHYLADRASITGKFSDDECLKLDVVFPHFISQIESMLTTGELNPRHAYCVILYH
NGFTCEADTLGSCGYVYISIYPTQR

Nucleotide

• Length: 318 bp

>AT169639 NZ_CP076646:c2676347-2676281 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT