Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 296619..297417 Replicon chromosome
Accession NZ_CP059917
Organism Escherichia coli strain 64.1

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag H5C78_RS01375 Protein ID WP_000854735.1
Coordinates 296619..296996 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag H5C78_RS01380 Protein ID WP_001285415.1
Coordinates 297043..297417 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C78_RS01345 291895..293433 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
H5C78_RS01350 294316..294642 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
H5C78_RS01355 294639..294902 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
H5C78_RS01360 294974..295840 - 867 WP_001280433.1 DUF4942 domain-containing protein -
H5C78_RS01365 295925..296122 - 198 WP_000839291.1 DUF957 domain-containing protein -
H5C78_RS01370 296134..296622 - 489 WP_000761677.1 hypothetical protein -
H5C78_RS01375 296619..296996 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
H5C78_RS01380 297043..297417 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H5C78_RS01385 297497..297718 - 222 WP_000692309.1 DUF987 domain-containing protein -
H5C78_RS01390 297781..298257 - 477 WP_001366855.1 RadC family protein -
H5C78_RS01395 298273..298752 - 480 WP_120136233.1 antirestriction protein -
H5C78_RS01400 298834..299652 - 819 WP_001175148.1 DUF945 domain-containing protein -
H5C78_RS01405 299742..299975 - 234 WP_001278287.1 DUF905 family protein -
H5C78_RS01410 299981..300658 - 678 WP_182917248.1 hypothetical protein -
H5C78_RS01415 300777..301661 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 284082..347348 63266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T169381 WP_000854735.1 NZ_CP059917:c296996-296619 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T169381 NZ_CP076450:c2281379-2280633 [Bacillus velezensis]
ATGCTTATGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGATGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT169381 WP_001285415.1 NZ_CP059917:c297417-297043 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT169381 NZ_CP076450:c2280632-2280462 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGCTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References