Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4755791..4756589 Replicon chromosome
Accession NZ_CP059907
Organism Escherichia coli strain 181.1

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag H5C80_RS23435 Protein ID WP_000854730.1
Coordinates 4756212..4756589 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag H5C80_RS23430 Protein ID WP_001285481.1
Coordinates 4755791..4756165 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5C80_RS23390 4751766..4752218 + 453 WP_000682723.1 hypothetical protein -
H5C80_RS23395 4752336..4752569 + 234 WP_001213776.1 DUF905 family protein -
H5C80_RS23400 4752669..4753490 + 822 WP_001234359.1 DUF945 domain-containing protein -
H5C80_RS23405 4753490..4753735 + 246 WP_001164966.1 hypothetical protein -
H5C80_RS23410 4753829..4754302 + 474 WP_001313575.1 antirestriction protein -
H5C80_RS23415 4754318..4754794 + 477 WP_001313574.1 RadC family protein -
H5C80_RS23420 4754857..4755078 + 222 WP_000692315.1 DUF987 domain-containing protein -
H5C80_RS23425 4755097..4755741 + 645 WP_000086759.1 hypothetical protein -
H5C80_RS23430 4755791..4756165 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H5C80_RS23435 4756212..4756589 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
H5C80_RS23440 4756586..4757078 + 493 Protein_4576 hypothetical protein -
H5C80_RS23445 4757157..4758145 - 989 Protein_4577 IS630 family transposase -
H5C80_RS23450 4758293..4759886 - 1594 Protein_4578 IS66 family transposase -
H5C80_RS23455 4759917..4760267 - 351 WP_182928168.1 IS66 family insertion sequence element accessory protein TnpB -
H5C80_RS23460 4760264..4760555 - 292 Protein_4580 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T169365 WP_000854730.1 NZ_CP059907:4756212-4756589 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T169365 NZ_CP076414:c1241915-1241169 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTGAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT169365 WP_001285481.1 NZ_CP059907:4755791-4756165 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT169365 NZ_CP076414:c1241168-1240998 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References