Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3567794..3568629 | Replicon | chromosome |
| Accession | NZ_CP059835 | ||
| Organism | Escherichia coli strain tcmA_3 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A4V2J0G6 |
| Locus tag | GQF93_RS17250 | Protein ID | WP_061360226.1 |
| Coordinates | 3567794..3568171 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7L7B777 |
| Locus tag | GQF93_RS17255 | Protein ID | WP_020218963.1 |
| Coordinates | 3568261..3568629 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF93_RS17215 (3562971) | 3562971..3563717 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| GQF93_RS17220 (3563771) | 3563771..3563992 | - | 222 | WP_212487173.1 | hypothetical protein | - |
| GQF93_RS27965 (3564004) | 3564004..3564090 | - | 87 | Protein_3400 | DUF5983 family protein | - |
| GQF93_RS17225 (3564101) | 3564101..3564802 | - | 702 | Protein_3401 | IS3-like element IS2 family transposase | - |
| GQF93_RS17230 (3564871) | 3564871..3565473 | - | 603 | WP_251365444.1 | IS21-like element helper ATPase IstB | - |
| GQF93_RS27970 (3565510) | 3565510..3565656 | - | 147 | WP_251365445.1 | hypothetical protein | - |
| GQF93_RS17235 (3565656) | 3565656..3566682 | - | 1027 | Protein_3404 | IS21 family transposase | - |
| GQF93_RS17240 (3566769) | 3566769..3567298 | - | 530 | Protein_3405 | IS3-like element IS2 family transposase | - |
| GQF93_RS17245 (3567390) | 3567390..3567797 | - | 408 | Protein_3406 | DUF5983 family protein | - |
| GQF93_RS17250 (3567794) | 3567794..3568171 | - | 378 | WP_061360226.1 | TA system toxin CbtA family protein | Toxin |
| GQF93_RS17255 (3568261) | 3568261..3568629 | - | 369 | WP_020218963.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| GQF93_RS17260 (3568679) | 3568679..3569323 | - | 645 | WP_020218962.1 | hypothetical protein | - |
| GQF93_RS17265 (3569338) | 3569338..3569559 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| GQF93_RS17270 (3569628) | 3569628..3570104 | - | 477 | WP_212487174.1 | RadC family protein | - |
| GQF93_RS17275 (3570119) | 3570119..3570604 | - | 486 | WP_000214404.1 | antirestriction protein | - |
| GQF93_RS17280 (3570696) | 3570696..3571514 | - | 819 | WP_001234380.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3559728..3570604 | 10876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14013.95 Da Isoelectric Point: 7.9086
>T169201 WP_061360226.1 NZ_CP059835:c3568171-3567794 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKQ
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKQ
Download Length: 378 bp
>T169201 NZ_CP076301:3873726-3874076 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13785.49 Da Isoelectric Point: 6.2066
>AT169201 WP_020218963.1 NZ_CP059835:c3568629-3568261 [Escherichia coli]
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT169201 NZ_CP076301:3873481-3873732 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4V2J0G6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7L7B777 |