Detailed information of TA system TA169108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2320..2834
• Replicon: plasmid unnamed2
• Accession: NZ_CP059727
• Organism: Bartonella sp. HY038

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H3299_RS15435
• Protein ID: WP_182419981.1
• Coordinates: 2568..2834 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: H3299_RS15430
• Protein ID: WP_182419980.1
• Coordinates: 2320..2568 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3299_RS15420	659..1720	+	1062	WP_182419978.1	replication initiator protein A	-
H3299_RS15425	1728..2177	-	450	WP_182419979.1	hypothetical protein	-
H3299_RS15430	2320..2568	+	249	WP_182419980.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H3299_RS15435	2568..2834	+	267	WP_182419981.1	Txe/YoeB family addiction module toxin	Toxin
H3299_RS15440	3852..5285	-	1434	WP_182419982.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..18722	18722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10677.16 Da
• Isoelectric Point: 9.3934

>T169108 WP_182419981.1 NZ_CP059727:2568-2834 [Bartonella sp. HY038]
MKLTFSTEAWEDYQYWISTDKKKLERINEIITQCQRTPYKGIGKPEPLKGDLSGWWSRRITQEHRIVYRISEEKQAQSLE
IAQLRFHY

Nucleotide

• Length: 267 bp

>T169108 NZ_CP076279:c285950-285672 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9043.11 Da
• Isoelectric Point: 5.0080

>AT169108 WP_182419980.1 NZ_CP059727:2320-2568 [Bartonella sp. HY038]
MNVISYSNARAQLKDVMDSAIHDKQEVVVSRKNGEAVVVISLETWNSISETLHLLSTPNNASRLRSAIAQLDANNGEEHE
LI

Nucleotide

• Length: 249 bp

>AT169108 NZ_CP076279:c286213-285953 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA