Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3512291..3513862 Replicon chromosome
Accession NZ_CP059690
Organism Proteus penneri strain S178-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H1225_RS15710 Protein ID WP_161669190.1
Coordinates 3512291..3513604 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H1225_RS15715 Protein ID WP_239739248.1
Coordinates 3513605..3513862 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1225_RS15690 3507464..3508258 + 795 WP_239739246.1 energy transducer TonB -
H1225_RS15695 3508320..3510284 - 1965 WP_239739247.1 hypothetical protein -
H1225_RS15700 3510308..3511240 - 933 WP_109848241.1 metallophosphoesterase -
H1225_RS15705 3511421..3511885 - 465 WP_006534283.1 DUF1097 domain-containing protein -
H1225_RS15710 3512291..3513604 - 1314 WP_161669190.1 type II toxin-antitoxin system HipA family toxin Toxin
H1225_RS15715 3513605..3513862 - 258 WP_239739248.1 helix-turn-helix domain-containing protein Antitoxin
H1225_RS15720 3514011..3515375 - 1365 WP_006534279.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
H1225_RS15725 3515506..3517146 - 1641 WP_072064719.1 membrane protein insertase YidC -
H1225_RS15730 3517149..3517409 - 261 WP_072064717.1 membrane protein insertion efficiency factor YidD -
H1225_RS15735 3517373..3517732 - 360 WP_071788569.1 ribonuclease P protein component -
H1225_RS15740 3517750..3517893 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49633.72 Da        Isoelectric Point: 6.1362

>T169059 WP_161669190.1 NZ_CP059690:c3513604-3512291 [Proteus penneri]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYHKLDDTELEKILLGYQSNTPLGMLEEYPDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCSIIKTKNIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLAPLYDIMSIYPNFGGKGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSKILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARVVRLANI

Download         Length: 1314 bp

>T169059 NZ_CP076274:c1772815-1771493 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9820.44 Da        Isoelectric Point: 10.3841

>AT169059 WP_239739248.1 NZ_CP059690:c3513862-3513605 [Proteus penneri]
MIIINAYQLSVHLKDVRLTKKLSQSKVAKKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKGAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT169059 NZ_CP076274:c1773081-1772815 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References