Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 459713..460308 Replicon chromosome
Accession NZ_CP059569
Organism Kingella oralis strain DSM 18271

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H3L93_RS02460 Protein ID WP_003797359.1
Coordinates 459901..460308 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H3L93_RS02455 Protein ID WP_003797363.1
Coordinates 459713..459898 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L93_RS02430 454791..455660 + 870 WP_003797374.1 CBS domain-containing protein -
H3L93_RS02435 455756..456301 + 546 WP_003797373.1 RNA 2'-phosphotransferase -
H3L93_RS02440 456525..457469 + 945 WP_003797368.1 class I SAM-dependent methyltransferase -
H3L93_RS02445 457617..458741 + 1125 WP_155803171.1 phospholipase A -
H3L93_RS02450 458872..459531 + 660 WP_003797365.1 DUF502 domain-containing protein -
H3L93_RS02455 459713..459898 + 186 WP_003797363.1 hypothetical protein Antitoxin
H3L93_RS02460 459901..460308 + 408 WP_003797359.1 tRNA(fMet)-specific endonuclease VapC Toxin
H3L93_RS02465 460377..460964 + 588 WP_003797358.1 NAD(P)H-dependent oxidoreductase -
H3L93_RS02470 461044..461979 + 936 WP_003797357.1 restriction endonuclease -
H3L93_RS02475 462090..463898 + 1809 WP_003797356.1 aspartate--tRNA ligase -
H3L93_RS02480 463979..464299 - 321 WP_003797353.1 iron-sulfur cluster assembly protein IscA -
H3L93_RS02485 464374..464757 - 384 WP_003797351.1 Fe-S cluster assembly scaffold IscU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15501.71 Da        Isoelectric Point: 7.4708

>T168983 WP_003797359.1 NZ_CP059569:459901-460308 [Kingella oralis]
MLKYMLDTNIVIYVMKQNPIEVLDTFNRHAAHLCISSITAAELYYGAEKSSFPERNLQRAEDFMSRLQVLSYGIKAATHF
GNIRYELQKQGQLIGENNMHIAAHARSEGLVLVSNNLREFERVAGLRFENWVTSH

Download         Length: 408 bp

>T168983 NZ_CP076268:c530856-530638 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6866.57 Da        Isoelectric Point: 4.5813

>AT168983 WP_003797363.1 NZ_CP059569:459713-459898 [Kingella oralis]
MPYSARFDEHVTHVNVRVVGNERIISPANQVWDSFFLSGNTASADFMAERETAVQPERDGL

Download         Length: 186 bp

>AT168983 NZ_CP076268:c531256-530882 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References