Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 2080161..2080773 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H2515_RS10330 Protein ID WP_198660034.1
Coordinates 2080161..2080478 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag H2515_RS10335 Protein ID WP_198660035.1
Coordinates 2080480..2080773 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS10305 2076059..2076601 - 543 WP_035194223.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
H2515_RS10310 2076620..2077714 - 1095 WP_065413963.1 CDP-glucose 4,6-dehydratase -
H2515_RS10315 2077758..2078543 - 786 WP_065413964.1 glucose-1-phosphate cytidylyltransferase -
H2515_RS10320 2078626..2079867 - 1242 WP_198660033.1 ATP-binding protein -
H2515_RS10325 2079978..2080094 + 117 Protein_2022 nucleotidyltransferase domain-containing protein -
H2515_RS10330 2080161..2080478 + 318 WP_198660034.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2515_RS10335 2080480..2080773 + 294 WP_198660035.1 putative addiction module antidote protein Antitoxin
H2515_RS10340 2080989..2081381 + 393 WP_198660036.1 nucleotidyltransferase substrate binding protein -
H2515_RS10345 2081374..2081688 + 315 WP_014028564.1 nucleotidyltransferase domain-containing protein -
H2515_RS10350 2081705..2082577 - 873 WP_198660037.1 ATP-binding protein -
H2515_RS10355 2082641..2083198 + 558 WP_035194211.1 septation protein A -
H2515_RS10360 2083286..2083588 + 303 WP_014028558.1 YciI family protein -
H2515_RS10365 2083585..2083896 + 312 WP_198660038.1 BolA family transcriptional regulator -
H2515_RS10370 2083907..2085220 + 1314 WP_198660039.1 amino-acid N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-99)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11927.68 Da        Isoelectric Point: 10.3141

>T168937 WP_198660034.1 NZ_CP059488:2080161-2080478 [Acidithiobacillus ferrivorans]
MGHVTIELKQTETFRKWWTKLKDERARGLISARLNRLAYGHAGDVEPVGEGISKLRIHYGPGYRVYFEKRGDTIIVLLCG
GDKSTQERDIKAAKRIAGKVDERSN

Download         Length: 318 bp

>T168937 NZ_CP076262:c500695-500477 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10220.64 Da        Isoelectric Point: 5.7928

>AT168937 WP_198660035.1 NZ_CP059488:2080480-2080773 [Acidithiobacillus ferrivorans]
MTEQQLTTFDPAEGLTSDEAIAVFMANAFESGDAGYIAHALGVVARVKGMAQIAGQTGLSREQLYRSFSERGNPTLKTTL
AVMKALGIELTAKGRAA

Download         Length: 294 bp

>AT168937 NZ_CP076262:c501095-500721 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References