Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4360208..4360924 Replicon chromosome
Accession NZ_CP059481
Organism Enterobacter kobei strain IB2020

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag H1R18_RS21950 Protein ID WP_178295056.1
Coordinates 4360208..4360549 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag H1R18_RS21955 Protein ID WP_178295058.1
Coordinates 4360574..4360924 (-) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1R18_RS21925 4356407..4357204 - 798 WP_178295050.1 helix-turn-helix transcriptional regulator -
H1R18_RS21935 4358665..4358931 - 267 WP_182115527.1 type II toxin-antitoxin system RelE/ParE family toxin -
H1R18_RS21940 4358935..4359183 - 249 WP_049023649.1 ribbon-helix-helix domain-containing protein -
H1R18_RS21945 4359260..4360093 - 834 WP_178295054.1 DUF4942 domain-containing protein -
H1R18_RS21950 4360208..4360549 - 342 WP_178295056.1 TA system toxin CbtA family protein Toxin
H1R18_RS21955 4360574..4360924 - 351 WP_178295058.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H1R18_RS21960 4360943..4361164 - 222 WP_178295060.1 DUF987 domain-containing protein -
H1R18_RS21965 4361185..4361631 - 447 WP_049023656.1 DNA repair protein RadC -
H1R18_RS21970 4361676..4362152 - 477 WP_178295062.1 antirestriction protein -
H1R18_RS21975 4362386..4363177 - 792 WP_182115615.1 DUF945 domain-containing protein -
H1R18_RS21980 4363231..4364823 - 1593 WP_044596437.1 IS66 family transposase -
H1R18_RS21985 4364854..4365204 - 351 WP_021567584.1 IS66 family insertion sequence element accessory protein TnpB -
H1R18_RS21990 4365201..4365608 - 408 WP_048242260.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 4323073..4387807 64734
- inside IScluster/Tn - - 4353360..4365204 11844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12995.97 Da        Isoelectric Point: 7.8847

>T168919 WP_178295056.1 NZ_CP059481:c4360549-4360208 [Enterobacter kobei]
MKTLPANQRVAKPCPPLVLVWQTLLTRLLEQHYGLTLNDTPFCDETVIQEHINAGITLADAVNFLVEKYELARIDRRGFS
WQEQSPYLRAVDILRARQATGLLLRQDHNLSTR

Download         Length: 342 bp

>T168919 NZ_CP076259:c2073755-2073652 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13255.13 Da        Isoelectric Point: 7.0265

>AT168919 WP_178295058.1 NZ_CP059481:c4360924-4360574 [Enterobacter kobei]
MPNNTPPVNHDITKPWWGLKRSITPCFGARLVQEGNRLHYLADRASIIGQFSDADLRHLDQAFPVLMKQLELMLTSGELN
PRHQHCVTLYHNELTCEADTLGSCGYVYLAFYPTQR

Download         Length: 351 bp

>AT168919 NZ_CP076259:2073614-2073885 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References