Detailed information of TA system TA168906

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1165444..1166122
• Replicon: chromosome
• Accession: NZ_CP059481
• Organism: Enterobacter kobei strain IB2020

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H1R18_RS06545
• Protein ID: WP_080781780.1
• Coordinates: 1165444..1165767 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H1R18_RS06550
• Protein ID: WP_080781779.1
• Coordinates: 1165799..1166122 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1R18_RS06515	1160637..1161380	+	744	Protein_1076	DUF4127 family protein	-
H1R18_RS06520	1161405..1161716	+	312	WP_045269204.1	PTS sugar transporter subunit IIB	-
H1R18_RS06525	1161752..1162057	+	306	WP_045269205.1	PTS lactose/cellobiose transporter subunit IIA	-
H1R18_RS06530	1162065..1162922	+	858	WP_045269206.1	MurR/RpiR family transcriptional regulator	-
H1R18_RS06535	1162975..1164021	+	1047	WP_052684066.1	porin	-
H1R18_RS06540	1164318..1164674	-	357	WP_014884928.1	hypothetical protein	-
H1R18_RS06545	1165444..1165767	-	324	WP_080781780.1	TA system toxin CbtA family protein	Toxin
H1R18_RS06550	1165799..1166122	-	324	WP_080781779.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H1R18_RS06555	1166144..1166365	-	222	WP_080781778.1	DUF987 domain-containing protein	-
H1R18_RS06560	1166374..1166844	-	471	WP_032642914.1	DNA repair protein RadC	-
H1R18_RS06565	1166877..1167695	-	819	WP_080781777.1	DUF945 domain-containing protein	-
H1R18_RS06570	1168041..1168226	+	186	WP_182115547.1	hypothetical protein	-
H1R18_RS06575	1168265..1169245	-	981	WP_000019473.1	IS5-like element ISKpn26 family transposase	-
H1R18_RS06580	1169271..1170152	+	882	WP_182115548.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1168265..1169245	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-106)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12047.85 Da
• Isoelectric Point: 6.4783

>T168906 WP_080781780.1 NZ_CP059481:c1165767-1165444 [Enterobacter kobei]
MQISSVPATVPVSSRLSPVMVWQQLLTYLLEHHYGLTLNDTPFHDDTAIQGHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQEQTPFITATDILRAKKSIGLLPRS

Nucleotide

• Length: 324 bp

>T168906 NZ_CP076258:c1649134-1648826 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAATCGAGAAGATACAGTCAAACACCCATATTTACTGGACATTCAAAGTAATATTATTGA
TATATTGAATACTCTTTTAGTCATCCCGTTATTCGATAGCAGGCTAGTTAAAAAACCATTACCTACTTGCCTTAACCCCC
AGTTATTTAGCAACGGGCAGGTGTTTGTTTTAATGACACACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTGAACTGCCAACAAAACACGATTAAACACGCAATTGACTTACTTATTGATGGCTTTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12029.77 Da
• Isoelectric Point: 6.3116

>AT168906 WP_080781779.1 NZ_CP059481:c1166122-1165799 [Enterobacter kobei]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNEEEALCLDQAFPLVMKQLELMLTTGELNPRHQHCVTLYHN
GLTCEADTLGSHGYVYIVIYPQAFATR

Nucleotide

• Length: 324 bp

>AT168906 NZ_CP076258:c1649334-1649134 [Providencia rettgeri]
ATCACTGTAGCGCCTGAGCTCTGCGAACAAGCATGGCGGGCTAAACTCAACTTATCTGCAATACTAACTTGTGCCTTACA
AGCTGAATTAAAACGCCTAGAAGCACAAAAGTGGAAAAATGAAAATATCGAAGGTTTTAATCAATTAAATAGGAACAATG
AAGAATACGGATTACTCTCAGATAAATACAAGGTTTTTTAA