Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 914906..915563 Replicon chromosome
Accession NZ_CP059481
Organism Enterobacter kobei strain IB2020

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag H1R18_RS05370 Protein ID WP_014885136.1
Coordinates 915153..915563 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag H1R18_RS05365 Protein ID WP_010435322.1
Coordinates 914906..915172 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1R18_RS05345 910340..911773 - 1434 WP_050862329.1 6-phospho-beta-glucosidase -
H1R18_RS05350 911890..912621 - 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
H1R18_RS05355 912887..913546 + 660 WP_023331242.1 hemolysin III family protein -
H1R18_RS05360 913631..914611 - 981 WP_014885137.1 tRNA-modifying protein YgfZ -
H1R18_RS05365 914906..915172 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
H1R18_RS05370 915153..915563 + 411 WP_014885136.1 protein YgfX Toxin
H1R18_RS05375 915569..916090 - 522 WP_050862328.1 flavodoxin FldB -
H1R18_RS05380 916192..917088 + 897 WP_050862327.1 site-specific tyrosine recombinase XerD -
H1R18_RS05385 917117..917830 + 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1R18_RS05390 917836..919569 + 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T168905 WP_014885136.1 NZ_CP059481:915153-915563 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T168905 NZ_CP076258:c899695-899492 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTGAGAAAATGCACAACAATTGAAACACTTGAGCGTGTCATTGAAAAAAACAA
GTATGAACTATCTGATGATGAACTAGAGTTATTCTACTCAGCGGCAGATCATCGTCTTGCTGAACTCACTATGAATAAGC
TCTACGATAAAATTCCACCTTCTGTATGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT168905 WP_010435322.1 NZ_CP059481:914906-915172 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168905 NZ_CP076258:c900138-899770 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAACAGTCTCAATAGAGACGCTATCTT
AAGTTTGCAAAAAACCAACACACATTGGATTAACGATCTAAGCTCTGCACAAAGTGCAGCTCTAAATGAACTCATTGAAC
ATATCGCAGCTTTTGTCTGGCGATTTAAGATCAAATATCCAAAAGAAAATCTCGTTATATCATTAATTGAAGAGTACCTC
GATGAGACTTATGACTTATTTGGTAGCCCAGTCATCACATTAAGTGAAATTATAGATTGGGAAACTATGAATCAAAATCT
AGTTTCAGTGCTGGATGATGACCTAAAATGTCTGACCAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References