168892

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 245089..245840 Replicon plasmid pIncHI1B_FIB
Accession NZ_CP059469
Organism Klebsiella pneumoniae strain BA25665

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag HBJ46_RS27595 Protein ID WP_014386536.1
Coordinates 245089..245571 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag HBJ46_RS27600 Protein ID WP_004902250.1
Coordinates 245562..245840 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ46_RS27575 (HBJ46_027455) 241488..242135 - 648 WP_014386537.1 EcsC family protein -
HBJ46_RS27580 (HBJ46_027460) 242162..242917 - 756 WP_004902235.1 DUF2971 domain-containing protein -
HBJ46_RS27585 (HBJ46_027465) 243018..243410 - 393 WP_032442757.1 hypothetical protein -
HBJ46_RS27590 (HBJ46_027470) 243515..244054 - 540 WP_004902239.1 hypothetical protein -
HBJ46_RS27595 (HBJ46_027475) 245089..245571 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
HBJ46_RS27600 (HBJ46_027480) 245562..245840 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
HBJ46_RS27605 (HBJ46_027485) 245959..246171 - 213 WP_004902255.1 hypothetical protein -
HBJ46_RS27610 (HBJ46_027490) 246279..246620 - 342 WP_004902257.1 hypothetical protein -
HBJ46_RS27615 (HBJ46_027495) 247450..247908 - 459 WP_014386535.1 hypothetical protein -
HBJ46_RS27620 (HBJ46_027500) 248561..249016 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
HBJ46_RS27625 (HBJ46_027505) 249088..249453 + 366 WP_004200999.1 mercuric ion transporter MerT -
HBJ46_RS27630 (HBJ46_027510) 249469..249744 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
HBJ46_RS27635 (HBJ46_027515) 249772..250197 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-15 / aac(6')-Ib / blaTEM-1A / tet(D) / dfrA14 / qnrB1 / blaOXA-1 / aac(6')-Ib-cr / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..289419 289419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T168892 WP_014386536.1 NZ_CP059469:c245571-245089 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T168892 NZ_CP076253:c4088496-4088344 [Xanthomonas translucens pv. graminis]
ATGAAGCGACTGTTCACCTTGATGATGCTGACCCTGTTCTGTGCAGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
TGGCAAGGATATGCAGAAGGCCGGCGATAAGGTGGAAAACAAGGCCGACGACTGCAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT168892 WP_004902250.1 NZ_CP059469:c245840-245562 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT168892 NZ_CP076253:c4088245-4088111 [Xanthomonas translucens pv. graminis]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTTTCGGTAGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References