Detailed information of TA system TA168741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2231696..2232375
• Replicon: chromosome
• Accession: NZ_CP059354
• Organism: Acinetobacter baumannii strain 2014BJAB1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: H1I70_RS10645
• Protein ID: WP_000838146.1
• Coordinates: 2232193..2232375 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: H1I70_RS10640
• Protein ID: WP_000966688.1
• Coordinates: 2231696..2232100 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1I70_RS10625	2230233..2230391	-	159	WP_004793704.1	hypothetical protein	-
H1I70_RS10630	2230514..2231014	-	501	WP_004793705.1	hypothetical protein	-
H1I70_RS10635	2231079..2231597	-	519	WP_004793706.1	DUF4468 domain-containing protein	-
H1I70_RS10640	2231696..2232100	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H1I70_RS10645	2232193..2232375	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
H1I70_RS10650	2232701..2233216	-	516	WP_017817058.1	hypothetical protein	-
H1I70_RS10655	2233286..2234203	-	918	WP_024435783.1	hypothetical protein	-
H1I70_RS10660	2234256..2235611	-	1356	WP_038345386.1	hypothetical protein	-
H1I70_RS10665	2235611..2235964	-	354	WP_000064601.1	hypothetical protein	-
H1I70_RS10670	2236023..2236241	-	219	WP_038340131.1	hypothetical protein	-
H1I70_RS10675	2236243..2236641	-	399	WP_038340137.1	hypothetical protein	-
H1I70_RS10680	2236643..2237011	-	369	WP_038340144.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2212261..2265348	53087

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T168741 WP_000838146.1 NZ_CP059354:c2232375-2232193 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T168741 NZ_CP076235:2275528-2275631 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT168741 WP_000966688.1 NZ_CP059354:c2232100-2231696 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT168741 NZ_CP076235:c2275669-2275398 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6