Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4728886..4729402 Replicon chromosome
Accession NZ_CP059312
Organism Klebsiella pneumoniae strain Kp46596

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag H1D28_RS25725 Protein ID WP_009486548.1
Coordinates 4728886..4729170 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H1D28_RS25730 Protein ID WP_002886901.1
Coordinates 4729160..4729402 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D28_RS25700 4724303..4724611 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
H1D28_RS25705 4724696..4724869 + 174 WP_032433782.1 hypothetical protein -
H1D28_RS25710 4724872..4725615 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
H1D28_RS25715 4725972..4728110 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
H1D28_RS25720 4728418..4728882 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H1D28_RS25725 4728886..4729170 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1D28_RS25730 4729160..4729402 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H1D28_RS25735 4729480..4731390 - 1911 WP_009486549.1 BglG family transcription antiterminator -
H1D28_RS25740 4731413..4732567 - 1155 WP_002886900.1 lactonase family protein -
H1D28_RS25745 4732634..4733374 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T168610 WP_009486548.1 NZ_CP059312:c4729170-4728886 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T168610 NZ_CP076136:c1140528-1140295 [Bradyrhizobium sediminis]
ATGGTCCCGAAGGGCTTCCCTGCAAATCTCGCCAAGGTTGCTCGGCGAAAGCTGATCATGGTGGACTCAGCGGACCTACT
CGAGGCTCTGAACTCGCCTCCCGGCAACCGCCTCGAAGCCCTAAAAGGCGATTTGGCGGGCAAGCACTCGATCCGGATCA
ATGATCAATGGCGGGTCGTGTTCCGTTGGACCGACGCGGGTCCGGAAGACGTGGAGATAGTCGACTATCATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT168610 WP_002886901.1 NZ_CP059312:c4729402-4729160 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT168610 NZ_CP076136:c1140251-1139955 [Bradyrhizobium sediminis]
ATGGCAAGAAAACTTCCGCCGGTTCATCCCGGCGAAGTGCTGCGGGAGGAGTTTCTCGTTCCGCTCAAGCTCACCCCTTA
CGCGGTCGCGGCTGCGCTGAACGTGCCGCGCACCCGGATCGAACGCATCGCGCGGGAGGAAAAGCCCGTTACGGCCGACA
CCGCGCTACGGCTTGGCAAGTTTTTCAAGACCGGCGCTGCGTTCTGGATGAATATGCAGGCACGCTTCGATCTCGAAACG
GCCGAAGACGTACTTGCGCCCCAGATCAAGAAGATTGCGTCCTACGAGGCGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References